Original Article

Single-Institution Experience of Synovial Sarcoma

Authors: Amy Farkas, MD, Seth T. Lirette, PhD, Youssef Al Hmada, MD, Anderson B. Collier, MD, Jennifer Barr, MD, Srinivasan Vijayakumar, MD, Vani Vijayakumar, MD

Abstract

Objectives: The purpose of this study was to investigate the patient population and outcomes of synovial sarcoma at a single institution.

Methods: A retrospective review of the medical records of 28 patients with synovial sarcoma diagnosed from 1992 to 2017 was performed. Demographics, staging, disease location, treatment, and response to treatment were reviewed.

Results: Individuals with larger tumors at the time of presentation had an increased risk of death. An additional factor associated with poor prognosis in synovial sarcoma was increasing patient age. The patient population had a higher rate of nonextremity disease and lower overall survival when compared with national averages.

Conclusions: Nonextremity disease and large size of tumor at presentation may have contributed to the disparity in institutional outcomes from the national averages. The advanced presentation of synovial sarcoma remains a significant challenge in improving patient survival.
Posted in: Medical Oncology8

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References

1. Wang S, Song R, Sun T, et al. Survival changes in patients with synovial sarcoma, 1983-2012. J Cancer 2017;8:1759-1768.
2. Murphey MD, Gibson MS, Jennings BT, et al. From the archives of the AFIP: imaging of synovial sarcoma with radiologic-pathologic correlation. Radiographics 2006;26:1543-1565.
3. Ferrari A, Gronchi A, Casanova M, et al. Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution. Cancer 2004;101:627-634.
4. Shi W, Indelicato DJ, Morris CG, et al. Long-term treatment outcomes for patients with synovial sarcoma: a 40-year experience at the University of Florida. Am J Clin Oncol 2013;36:83-88.
5. Wigland MC, Hoffman TK, Barth TFE, et al. Biphasic synovial sarcoma of the epiglottis: case report and literature review. Auris Nasus Larynx 2018;45:617-621.
6. Doroudinia A, Bakhshayesh Karam M, Dorudinia A, et al. Synovial sarcoma of the esophagus: a case report and review of literature. Middle East J Dig Dis 2017;9:111-113.
7. Sbaraglia M, Dei Tos AP. The pathology of soft tissue sarcomas. Radiol Med 2019;124:266-281.
8. US Census Bureau. QuickFacts Mississippi. https://www.census.gov/quickfacts/MS. Accessed October 28, 2019.
9. Richardson MA, Tarsi EJ, Replogle WH, et al. Socioeconomic disparities in Mississippi head and neck cancer patients. Otolaryngol Head Neck Surg 2013;149(2 suppl):P195.