The Southern Medical Journal (SMJ) is the official, peer-reviewed journal of the Southern Medical Association. It has a multidisciplinary and inter-professional focus that covers a broad range of topics relevant to physicians and other healthcare specialists.

SMJ // Article

Review Article

Sports Concussion Management: Part I

Authors: Thomas R. Terrell, MD, MPhil, Timothy Nobles, BA, Brianna Rader, Kenneth Bielak, MD, MBA, Irfan Asif, MD, Robert Casmus, BA, Jamie Yeager, BS, Reem Hussein, BA

Abstract

Concussion is a popular clinical topic that has been the subject of unprecedented recent media coverage. As concerns about the potential short- and long-term implications of repetitive head injury in sports such as football continue to mount, the proper clinical management of concussion seems to increase in importance. The days of ignoring the ‘‘ding’’ on the sideline are definitely over. A series of updated clinical evaluation and management recommendations from international experts are highlighted in this review. The clinical presentation of an acute concussion, both the typical and more subtle
variations, may be evaluated with new validated sideline evaluation tools (eg, Sports Concussion Assessment Tool 2). In addition, the role of computerized neuropsychological and balance testing in the acute and ongoing evaluation are discussed, along with how they contribute to the return-to-play decision. Same-day return to play is outdated,
and the relative insensitivity of current neuroimaging modalities to demonstrate structural damage is highlighted. New therapeutic interventions such as amantadine and cognitive rest may improve recovery time. The appropriate management of concussion typically results in a normal functional and neurocognitive outcome. The recommendations in this article may guide clinicians, with varying degrees of prior experience managing concussion, to increase the likelihood of an excellent outcome.

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References

1. Langlois, JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil 2006;21:375-378.
 
2. McCrea M, Hammeke T, Olsen G, et al. Unreported concussion in high school football players: implications for prevention. Clin J Sport Med 2004;14:13-17.
 
3. Field M, Collins MW, Lovell MR, et al. Does age play a role in recovery from sports-related concussion? A comparison of high school and collegiate athletes. J Pediatr 2003;142:546-553.
 
4. Delaney J, Lacroix VJ, Leclerc S, et al. Concussions among university football and soccer players. Clin J Sports Med 2002;12:331-338.
 
5. McCrory P, Meeuwisse WH, Aubry M, et al. Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012.Br J Sports Med 2013;47:250-258.
 
6. Guskiewicz KM, McCrea M, Marshall SW, et al. Cumulative effects associated with recurrent concussion in collegiate football players: the NCAA Concussion Study. JAMA 2003;290:2549-2555.
 
7. Ellenbogen RG, Berger MS, Batjer HH. The National Football League and concussion: leading a culture change in contact sports. World Neurosurg 2010;74:560-565.
 
8. Jaffee MS, Helmick KM, Girard PD, et al. Acute clinical care and care coordination for traumatic brain injury within Department of Defense. J Rehabil Res Dev 2009;46:655-666.
 
9. Gavett BE, Stern RA, McKee AC. Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma. Clin Sports Med 2011;30:179-188.
 
10. Vecsey G. College athletes move concussions into the courtroom. New York Times 2011:B14.
 
11. Latimer P. Schools adjust to new N.C. concussion law. http://www.starnewsonline.com/article/20110702/ARTICLES/110709944. Published July 2, 2011. Accessed August 4, 2012.
 
12. Terrell TR. Concussion in athletes. South Med J 2004;97:837-842.
 
13. Cantu RC. Second-impact syndrome. Clin Sports Med 1998;17:37-44.
 
14. Scorza KA, Raleigh MF, O’Connor FG. Current concepts in concussion: evaluation and management. Am Fam Physician 2012;85:123-132.
 
15. Harmon KG, Drezner J, Gammons M, et al. American Medical Society for Sports Medicine position statement: concussion in sport.Clin J Sport Med 2013;23:1-18.
 
16. Cantu RC. Posttraumatic retrograde and anterograde amnesia: pathophysiology and implications in grading and safe return to play. J Athl Train 2001;36:244-248.
 
17. Buzzini SR, Guskiewicz KM. Sport-related concussion in the young athlete. Curr Opin Pediatr 2006;18:376-382.
 
18. Guskiewicz KM. Assessment of postural stability following sport-related concussion. Curr Sports Med Rep 2003;2:24-30.
 
19. Jagoda AS, Bazarian JJ, Bruns JJ Jr, et al. Clinical policy: neuroimaging and decision making in adult mild traumatic brain injury in the acute setting. Ann Emerg Med 2008;52:714-748.
 
20. Van Boven RW, Harrington GS, Hackney DB, et al. Advances in neuroimaging of traumatic brain injury and posttraumatic stress disorder. J Rehabil Res Dev 2009;46:717-757.
 
21. Clark CM, Schneider JA, Bedell BJ. Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA 2011;305:275-283.
 
22. McCrea M. Standardized mental status testing on the sideline after sport-related concussion. J Athl Train 2001;36:274-279.
 
23. Johnson EW, Kegel NE, Collins MW. Neuropsychological assessment of sport-related concussion. Clin Sports Med 2011;30:73-88.
 
24. Erlanger DM, Feldman DJ, Kutner KC. HeadMinder: Concussion Resolution Index (CRI): Professional Manual. New York, HeadMinder, 2002.
 
25. Erlanger DM, Kaushik T, Broshek D, et al. Development and validation of a web-based screening tool for monitoring cognitive status. J Head Trauma Rehabil 2002;17:458-476.
 
26. Lovell MR, Iverson GL, Collins MW, et al. Measurement of symptoms following sports-related concussion: reliability and normative data for the post-concussion scale. Appl Neuropsychol 2006;13:166-174.
 
27. Iverson GL, Lovell MR, Collins MW. Validity of ImPACT for measuring processing speed following sports-related concussion. J Clin Exp Neuropsychol 2005;27:683-689.
 
28. Cernich A, Reeves D, Sun W, et al. Automated neuropsychological assessment metrics sports medicine battery. Arch Clin Neuropsychol 2007;22:S101-S114.
 
29. Collie A, Maruff, P, McStephen M, et al. Cogsport, in Echemendia RJ (ed): Sports Neuropsychology: A Clinical Primer. New York, Guilford Press, 2005:71-84.
 
30. Iverson GL, Brooks BL, Collins MW, et al. Tracking neuropsychological recovery following concussion in sport. Brain Inj 2006;20:245-252.
 
31. Talavage TM, Nauman E, Breedlove EL, et al. Functionally-detected cognitive impairment in high school football players without clinically-diagnosed concussion. J Neurotrauma 2013; [Epub ahead of print] .
 
32. McKee AC, Cantu RC, Nowinski CJ, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 2009;68:709-735.
 
33. McKee AC, Stern RA, Nowinski CJ, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain 2013;136:43-64.
 
34. Omalu BI, Fitzsimmons RP, Hammers J, et al. Chronic traumatic encephalopathy in a professional American wrestler. J Forensic Nurs 2010;6:130-136.
 
35. Omalu BI, DeKosky ST, Hamilton RL, et al. Chronic traumatic encephalopathy in a National Football League player: part II. Neurosurgery 2006;59:1086-1093.
 
36. Omalu BI, DeKosky ST, Minster RL, et al. Chronic traumatic encephalopathy in a National Football League player. Neurosurgery 2005;57: 128-134.
 
37. Schwarz A. Concussion trauma risk seen in amateur athlete. New York Times 2009:B14.
 
38. Lehman EJ, Hein MJ, Baron SL, et al. Neurodegenerative causes of death among retired National Football League players. Neurology 2012;79:1970-1974.
 
39. King NS. Post-concussion syndrome: clarity amid the controversy? Br J Psychiatry 2003;183:276-278.
 
40. Leddy JJ, Sandhu H, Sodhi V, et al. Rehabilitation of concussion and post-concussion syndrome. Sports Health 2012;4:147-154.
 
41. Leddy JJ, Kozlowski K, Donnelly JP, et al. A preliminary study of subsymptom threshold exercise training for refractory post-concussion syndrome. Clin J Sport Med 2010;20:21-27.
 
42. McKeag DB. Understanding sports-related concussion: coming into focus but still fuzzy. JAMA 2003;290:2604-2605.
 
43. Stricker PR, Moriarity J, O’Connor FG. Concussion. N Engl J Med 2007;356:1787-1788.
 
44. Putukian M. The acute symptoms of sport-related concussion: diagnosis and on-field management. Clin Sports Med 2011;30:49-61.
 
45. McCrory P. Recognizing exercise-related headache. Phys Sportsmed 1997;25:33-43.
 
46. Poirier MP. Concussions: assessment, management, and recommendations for return to activity. Clin Pediatr Emerg Med 2003;4:179-185.
 
47. Putukian M, Aubry M, McCrory P. Return to play after sports concussion in elite and non- elite athletes? Br J Sports Med 2009;43:i28-i31.
 
48. Shatz P, Putz BO. Cross-validation of measures used for computer-based assessment of concussion. Appl Neuropsychol 2006;13:151-159.
 
49. Herring SA, Cantu RC, Guskiewicz KM, et al. Concussion (mild traumatic brain injury) and the team physician: a consensus statementV2011 update. Med Sci Sports Exerc 2011;43:2412-2422.
 
50. Broglio SP, Macciocchi SN, Ferrara MS. Neurocognitive performance of concussed athletes when symptom free. J Athl Train 2007;42:504-508.
 
51. Valovich McLeod TC, Gioia GA. Cognitive rest: the often neglected aspect of concussion management. Athletic Ther Today 2010;15:1-3.
 
52. de Kruijk JR, Leffers P, Meerhoff S, et al. Effectiveness of bed rest after mild traumatic brain injury: a randomised trial of no versus six days of bed rest. J Neurol Neurosurg Psychiatry 2002;73:167-172.
 
53. Valentine V, Logan K. Cognitive rest in concussion management. Am Fam Physician 2012;85:100-101.
 
54. Moser RS, Glatts C, Schatz P. Efficacy of immediate and delayed cognitive and physical rest for treatment of sports-related concussion. J Pediatr 2012;161:922-926.
 
55. Beauchamp K, Mutlak H, Smith WR, et al. Pharmacology of traumatic brain injury: where is the ‘‘golden bullet’’? Mol Med 2008;14:731-740.
 
56. Lenaerts ME, Couch JR. Posttraumatic headache. Curr Treat Options Neurol 2004;6:507-517.
 
57. Samantaray S, Das A, Thakore NP, et al. Therapeutic potential of melatonin in traumatic central nervous system injury. J Pineal Res 2009;47:134-142.
 
58. Rao V, Rollings P. Sleep disturbances following traumatic brain injury. Curr Treat Options Neurol 2002;4:77-87.
 
59. Arciniegas DB, Anderson CA, Topkoff J, et al. Mild traumatic brain injury: a neuropsychiatric approach to diagnosis, evaluation and treatment. Neuropsychiatr Dis Treat 2005;1:311-327.
 
60. Giacino JT, Whyte J, Bagiella E, et al. Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med 2012;366:819-826.
 
61. Reddy CC, Collins M, Lovell M, et al. Amantadine treatment on symptoms and neurocognitive performance among adolescents following sports-related concussion. J Head Trauma Rehabil 2013;28:260-265.
 
62. Kraus MF, Smith GS, Butters M, et al. Effects of the dopaminergic agent and NMDA receptor antagonist amantadine on cognitive function, cerebral glucose metabolism and D2 receptor availability in chronic traumatic brain injury: a study using positron emission tomography (PET). Brain Inj 2005;19:471-479.
 
63. Schneider WN, Drew-Cates J, Wong TM, et al. Cognitive and behavioural efficacy of amantadine in acute traumatic brain injury: an initial double-blind placebo-controlled study. Brain Inj 1999;13;863-872.
 
64. Sivan M, Neumann V, Kent R, et al. Pharmacotherapy for treatment of attention deficits after non-progressive acquired brain injury. A systematic review. Clin Rehabil 2010;24:110-121.
 
65. Neurobehavioral Guidelines Working Group, Warden DL, Gordon B, et al. Guidelines for pharmacologic treatment of neurobehavioral sequelae of traumatic brain injury. J Neurotrauma 2006;23:1468-1501.
 
66. Chew E, Zafonte RD. Pharmacologic management of neurobehavioral disorders following traumatic brain injuryVa state-of-the-art review. J Rehabil Res Dev 2009:46:851-879.
 
67. National Collegiate Athletic Association. NCAA banned drug list. http://www.ncaa.org/wps/wcm/connect/public/NCAA/Health+and+Safety/Drug+Testing/Resources. Published January 4, 2013. Accessed December 17, 2013.
 
68. Fann JR, Uomoto JM, Katon WJ. Cognitive improvement with treatment of depression following mild traumatic brain injury. Psychosomatics 2001;42:48-54.
 
69. Meehan WP 3rd. Medical therapies for concussion. Clin Sports Med 2011;30:115-124.
 
70. Ech inter-organization position statement. Arch Clin Neuropsychol 2012;27:119-122.
 
71. Schnadower D, Vazquez H, Lee J, et al. Controversies in the evaluation and management of minor blunt head trauma in children. Curr Opin Pediatr 2007;19:258-264.
 
72. Yard EE, Comstock RD. Compliance with return to play guidelines following concussion in US high school athletes, 2005Y2008. Brain Inj 2009;23:888-898.
 
73. Hollis SJ, Stevenson MR, McIntosh AS, et al. Compliance with return-to-play regulations following concussion in Australian schoolboy and rugby union players. Br J Sports Med 2012;46:735-740.
 
74. Purcell L. What are the most appropriate return-to-play guidelines for concussed child athletes? Br J Sports Med 2009;43:i51-i55.
 
75. Cantu RC. Guidelines for return to contact sports after a cerebral concussion. Phys Sportsmed 1986;14:75-83.
 
76. Bailes JE, Cantu RC. Head injury in athletes.N eurosurgery 2001;48:26-45.
 
77. Wetjen NM, Pichelmann MA, Atkinson JL. Second impact syndrome: concussion and second injury brain complications. J Am Coll Surg 2010;211:553-557.
 
78. McCrory P, Davis G, Makdissi M. Second impact syndrome or cerebral swelling after sporting head injury. Curr Sports Med Rep 2012;11:21-23.
 
79. Legislative actions dealing with concussion policy in the United States. http://www.sportsconcussions.org/links/law-and-policy.html. Accessed November 1, 2012.
 
80. Terrell TR, Bostick RM, Abramson R, et al. APOE, APOE promoter, and Tau genotypes and risk for concussion in college athletes. Clin J Sport Med 2008;18:10-17.