The Southern Medical Journal (SMJ) is the official, peer-reviewed journal of the Southern Medical Association. It has a multidisciplinary and inter-professional focus that covers a broad range of topics relevant to physicians and other healthcare specialists.

SMJ // Article

Editorial

The Impact of Diabetes Mellitus On Endothelial Dysfunction

Authors: George Iype Varughese, MRCP

Abstract

Coronary artery, cerebrovascular and peripheral vascular disease (PVD) are the principal causes of morbidity and mortality in type 2 diabetes mellitus (DM).1 The augmented risk of macrovascular disease in DM is partly due to the considerably higher incidence of conventional cardiovascular risk factors, such as hypertension, obesity and dyslipidemia.2 However, we should not forget that the pathophysiology of complications in the setting of DM is multifactorial, and in addition to the “conventional” risk factors, there are many other closely inter-related processes that develop in parallel, progress with time, and are strongly and independently associated with the risk of death on a background of DM.1,3

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References

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