1. Ferrucci L, Cooper R, Shardell M, et al. Age-related change in mobility: perspectives from life course epidemiology and geroscience. J Gerontol A Biol Sci Med Sci 2016;71:1184–1194.
2. Rowe JW, Kahn RL. Successful aging. Gerontologist 1997;37:433–440.
3. Kodama S, Saito K, Tanaka S, et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA 2009;301:2024–2035.
4. Fritz S, M. Lusardi M. White paper: “walking speed: the sixth vital sign”. J Geriatr Phys Ther 2009;32:2–5.
5. Studenski S, Perera S, Patel K, et al. Gait speed and survival in older adults. JAMA 2011;305:50–58.
6. Van Kan GA, Rolland Y, Andrieu S, et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging 2009;13:881–889.
7. Kamiya K, Hamazaki N, Matsue Y, et al. Gait speed has comparable prognostic capability to six-minute walk distance in older patients with cardiovascular disease. Eur J Prev Cardiol 2018;25:212–219.
8. Hall WJ. Update in geriatrics. Ann Intern Med 2006;145:538–543.
9. Woo J. Walking speed: a summary indicator of frailty? J Am Med Dir Assoc 2015;16:635–637.
10. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56:M146–M157.
11. Barak Y, Wagenaar RC, Holt KG. Gait characteristics of elderly people with a history of falls: a dynamic approach. Phys Ther 2006;86:1501–1510.
12. Guralnik JM, Ferrucci L, Pieper CF, et al. Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci 2000;55:M221–M231.
13. Perera S, Patel KV, Rosano C, et al. Gait speed predicts incident disability: a pooled analysis. J Gerontol A Biol Sci Med Sci 2016;71:63–71.
14. Montero-Odasso M, Schapira M, Soriano ER, et al. Gait velocity as a single predictor of adverse events in healthy seniors aged 75 years and older. J Gerontol A Biol Sci Med Sci 2005:60:1304–1309.
15. Penninx BW, Ferrucci L, Leveille SG, et al. Lower extremity performance in nondisabled older persons as a predictor of subsequent hospitalization. J Gerontol A Biol Sci Med Sci 2000;55:M691–M697.
16. Kuate-Tegueu C, Avila-Funes J-A, Simo N, et al. Association of gait speed, psychomotor speed, and dementia. J Alzheimers Dis 2017;60:585–592.
17. Rosso AL, Verghese J, Metti AL, et al. Slowing gait and risk for cognitive impairment: the hippocampus as a shared neural substrate. Neurology 2017; 89:336–342.
18. Cooper R, Kuh D, Hardy R. Objectively measured physical capability levels and mortality: systematic review and meta-analysis. BMJ 2010;341:c4467.
19. Liu B, Hu X, Zhang Q, et al. Usual walking speed and all-cause mortality risk in older people: a systematic review and meta-analysis. Gait Posture 2016;44:172–177.
20. Veronese N, Stubbs B, Volpato S, et al. Association between gait speed with mortality, cardiovascular disease and cancer: a systematic review and meta-analysis of prospective cohort studies. J Am Med Dir Assoc 2018; 19:981–988.e7.
21. Haffar S, Shalimar, Kaur RJ, et al. Acute liver failure caused by hepatitis E virus genotype 3 and 4: a systematic review and pooled analysis. Liver Int 2018;38:1965–1973.
22. Zhao W, Ukawa S, Tsushita K, et al. Association of gait speed with mortality among the Japanese elderly in the New Integrated Suburban Seniority Investigation Project: a prospective cohort study. Age Ageing 2014;44: 153–157.
23. Imran TF, Orkaby A, Chen J, et al. Walking pace is inversely associated with risk of death and cardiovascular disease: the Physicians’ Health Study. Atherosclerosis 2019;289:51–56.
24. Petermann-Rocha F, Ho FK, Welsh P, et al. Physical capability markers used to define sarcopenia and their association with cardiovascular and respiratory outcomes and all-cause mortality: a prospective study from UK Biobank. Maturitas 2020;138:69–75.
25. Jotheeswaran A, Bryce R, Prina M, et al. Frailty and the prediction of dependence and mortality in low-and middle-income countries: a 10/66 population-based cohort study. BMC Med 2015;13:138.
26. Goldman N, Glei DA, Weinstein M. What matters most for predicting survival? A multinational population-based cohort study. PloS One 2016; 11:e0159273.
27. Berges I-M, Graham JE, Ostir GV, et al. Sex differences in mortality among older frail Mexican Americans. J Womens Health 2009;18:1647–1651.
28. Goldman N, Glei DA, Rosero-Bixby L, et al. Performance-based measures of physical function as mortality predictors: incremental value beyond selfreports. Demogr Res 2014;30:227.
29. Lee W-J, Peng L-N, Chiou S-T, et al. Physical health indicators improve prediction of cardiovascular and all-cause mortality among middle-aged and older people: a national population-based study. Sci Rep 2017;7:1–8.
30. Lee W-J, Peng L-N, Lin M-H, et al. Determinants and indicators of successful ageing associated with mortality: a 4-year population-based study. Aging (Albany NY) 2020;12:2670.
31. Keevil VL, Luben R, Hayat S, et al. Physical capability predicts mortality in late mid-life as well as in old age: findings from a large British cohort study. Arch Gerontol Geriatr 2018;74:77–82.
32. Sobestiansky S, Michaelsson K, Cederholm T. Sarcopenia prevalence and associations with mortality and hospitalisation by various sarcopenia definitions in 85–89 year old community-dwelling men: a report from the ULSAM study. BMC Geriatr 2019;19:318.
33. Hsu B, Merom D, Blyth FM, et al. Total physical activity, exercise intensity, and walking speed as predictors of all-cause and cause-specific mortality over 7 years in older men: the Concord Health and Aging in Men Project. J Am Med Dir Assoc 2018;19:216–222.
34. Stanaway FF, Gnjidic D, Blyth FM, et al. How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over. BMJ 2011;343:d7679.
35. Idland G, Engedal K, Bergland A. Physical performance and 13.5-year mortality in elderly women. Scand J Public Health 2013;41:102–108.
36. Blain H, Carriere I, Sourial N, et al. Balance and walking speed predict subsequent 8-year mortality independently of current and intermediate events in well-functioning women aged 75 years and older. J Nutr Health Aging 2010;14:595–600.
37. Rolland Y, Lauwers-Cances V, Cesari M, et al. Physical performance measures as predictors of mortality in a cohort of community-dwelling older French women. Eur J Epidemiol 2006;21:113–122.
38. Cesari M, Kritchevsky SB, Penninx BWHJ, et al. Prognostic value of usual gait speed in well-functioning older people—results from the Health, Aging and Body Composition Study. J Am Geriatr Soc 2005;53:1675–1680.
39. Cesari M, Kritchevsky SB, Newman AB, et al. Added value of physical performance measures in predicting adverse health-related events: results from the Health, Aging and Body Composition Study. J Am Geriatr Soc 2009;57:251–259.
40. Graham JE, Al Snih S, Berges IM, et al. Frailty and 10-year mortality in community-living Mexican American older adults. Gerontology 2009;55: 644–651.
41. Abe T, Kitamura A, Taniguchi Y, T., et al. Pathway from gait speed to incidence of disability and mortality in older adults: a mediating role of physical activity. Maturitas 2019;123:32–36.
42. Woo J, Ho SC, Yu AL. Walking speed and stride length predicts 36 months dependency, mortality, and institutionalization in Chinese aged 70 and older. J Am Geriatr Soc 1999;47:1257–1260.
43. Lyyra T-M, Leskinen E, Heikkinen E. A cohort study found good respiratory, sensory and motor functions decreased mortality risk in older people. J Clin Epidemiol 2005;58:509–516.
44. Elbaz A, Sabia S, Brunner E, et al. Association of walking speed in late midlife with mortality: results from the Whitehall II cohort study. Age (Dordr) 2013;35:943–952.
45. Yazdanyar A, Aziz MM, Enright PL, et al. Association between 6-minute walk test and all-cause mortality, coronary heart disease–specific mortality, and incident coronary heart disease. J Aging Health 2014;26:583–599.
46. Veronese N, Stubbs B, Fontana L, et al. A comparison of objective physical performance tests and future mortality in the elderly people. J Gerontol A Biol Sci Med Sci 2017;72:362–368.
47. Woo J, Yu R, Leung J. Predictive ability of individual items of the Cardiovascular Health Study (CHS) scale compared with the summative score. J Am Med Dir Assoc 2018;19:444–449.
48. Woo J, Yau F, Leung J, et al. Peak oxygen uptake, six-minute walk distance, six-meter walk speed, and pulse pressure as predictors of seven year all-cause and cardiovascular mortality in community-living older adults. Exp Gerontol 2019;124:110645.
49. Koivunen K, Sillanpää E, von Bonsdorff M, et al. Mortality risk among older people who did versus did not sustain a fracture: baseline pre-fracture strength and gait speed as predictors in a 15-year follow-up. J Gerontol A Biol Sci Med Sci 2020;75:1996–2002.
50. Verlinden VJ, van der Geest JN, Hoogendam YY, et al. Gait patterns in a community-dwelling population aged 50 years and older. Gait Posture 2013;37:500–505.
51. Dommershuijsen LJ, Isik BM, Darweesh SKL, et al. Unraveling the association between gait and mortality—one step at a time. J Gerontol A Biol Sci Med Sci 2020;75:1184–1190.
52. Rosero-Bixby L, Dow WH. Predicting mortality with biomarkers: a population-based prospective cohort study for elderly Costa Ricans. Popul Health Metrics 2012;10:11.
53. Sanders JB, Bremmer MA, Comijs HC, et al. Gait speed and processing speed as clinical markers for geriatric health outcomes. Am J Geriatr Psychiatry 2017;25:374–385.
54. Dumurgier J, Elbaz A, Ducimetière P, et al. Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study. BMJ 2009;339:b4460.
55. Boulifard DA, Ayers E, Verghese J. Home-based gait speed assessment: normative data and racial/ethnic correlates among older adults. J Am Med Dir Assoc 2019;20:1224–1229.
56. Vetrano DL, Landi F, De Buyser SL, et al. Predictors of length of hospital stay among older adults admitted to acute care wards: a multicentre observational study. Eur J Intern Med 2014;25:56–62.
57. Havighurst RJ. Successful aging. Gerontologist 1961;1:8–13.
58. Kim S, Myers L, Wyckoff J, et al. The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age. Geroscience 2017;39:83–92.
59. Applegate WB, Blass JP, Williams TF. Instruments for the functional assessment of older patients. N Engl J Med 1990;322:1207–1214.
60. Cesari M, Penninx BWJH, Pahor M, et al. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2004;59:M242–M248.
61. Elbaz A, Ripert M, Tavernier B, et al. Common carotid artery intima-media thickness, carotid plaques, and walking speed. Stroke 2005;36:2198–2202.
62. Lelli D, Tolone S, Pulignano G, et al. Nutritional status is associated with physical function and disability in older adults with chronic heart failure. Eur J Intern Med 2020;74:73–78.
63. Afilalo J, Eisenberg MJ, Morin J-F, et al. Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery. J Am Coll Cardiol 2010;56:1668–1676.
64. Wolfe A. Institute of Medicine report: crossing the quality chasm: a new health care system for the 21st century. Policy Politics Nurs Pract 2001;2: 233–235.
65. Pasma JH, Stijntjes M, Ou SS, et al. Walking speed in elderly outpatients depends on the assessment method. Age (Dordr) 2014;36:9736.
66. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994;49:M85–M94.
67. Pavasini R, Guralnik J, Brown JC, et al. Short physical performance battery and all-cause mortality: systematic review and meta-analysis. BMC Med 2016;14:215.