Breast cancer is the most common cancer next to skin cancer for women in the United States, and it is the second leading cause of cancer death after lung cancer. New cases of female breast cancer rose an average of 0.6% each year between 2013 and 2022. Fortunately, the death…
Breast cancer care is advancing at an extraordinary pace, yet each new answer seems to raise fresh questions for clinicians, researchers, and patients alike. With that dynamic landscape in mind, the Southern Medical Journal devotes this special issue to the latest insights across the continuum of breast cancer diagnosis, treatment,…
Objectives: Invasive breast cancer (IBC) is a heterogeneous disease, with molecular subtypes guiding treatment and prognosis. Radiotherapy, a key component of breast cancer therapy, may vary in efficacy across subtypes. This study assessed the distribution of molecular subtypes and the use of radiotherapy, as well as their associations with clinicopathological…
Objective: Multiple factors are associated with re-excision after breast-conserving surgery (BCS), however there is minimal literature discussing factors associated with re-excision after oncoplastic BCS (OBCS). This retrospective study aimed to identify factors associated with positive margins requiring re-excision after OBCS. Methods: A retrospective review was performed on patients who underwent…
Objectives: Axillary lymph node (ALN) metastases are difficult to diagnose in invasive lobular carcinoma (ILC). This study evaluated the use of axillary ultrasound (AUS) and magnetic resonance imaging (MRI) in predicting ALN metastases in patients with ILC tumors >5 cm, who are at high risk of axillary metastases. Methods: This…
Objectives: Pathogenic germline CDH1 variants result in increased risk of gastric (GC) and invasive lobular (ILC) carcinomas with high penetrance. Limited data suggest a higher incidence of colorectal neoplasia in carriers of CDH1 mutations, but data remain limited on the risk of colorectal adenoma formation and the role of colonoscopy…
Objective: Black women in Louisiana have an increased breast cancer incidence. In addition, mortality and incidence of breast cancer in younger patients are on the rise, regardless of race or germline mutations. Most available germline mutation data in breast cancer are based primarily on White patient populations. We sought to…
Objectives: Patients with a history of massive weight loss (MWL) frequently undergo body-contouring surgery such as abdominoplasty, and the safety profile of this procedure is well accepted. The deep inferior epigastric artery perforator (DIEP) flap is a procedure where excess abdominal tissue is used to reconstruct the breast. The abdominal…
Objectives: The RxPONDER trial showed premenopausal patients with pT1-2 N1 hormone receptor-positive (HR+)/HER2− breast cancer benefit from chemotherapy regardless of 21-gene recurrence score (RS), but it did not analyze whether the number of positive lymph nodes (+LNs) was correlative of outcomes. Our study sought to evaluate whether the number of…
There are similarities between neuroendocrine tumors (NET) and primary breast cancers. A misdiagnosis can significantly affect prognosis and patient treatment plans, leading to potential catastrophic effects on patient care. In this study, we look at two cases in which NET was misdiagnosed as a primary breast cancer, in the breast…
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