Case Report

Abnormal Lactate Dehydrogenase Isoenzyme Pattern in a Critically Ill Patient

Authors: C. ANDREW ROBINSON JR. PhD, CATHERINE H. KETCHUM MS, WILLIAM E. GRIZZLE MD, PhD, LEO M. HALL PhD, C. BRUCE ALEXANDER MD

Abstract

SUMMARYWe have described a patient who had an abnormal isoenzyme of lactate dehydrogenase in both serum and tissue. The presence of LDB is indicative of a poor prognosis. Some of the biochemical characteristics of the isoenzyme are (1) LD6 is not an artifact, (2) it contains an M subunit but not an H subunit, and (3) it is not an immunoglobulin complex. We believe LD6 may arise during episodes of severe shock as lysosomes rupture and is either a previously sequestered lysosomal LD or is a lysosomal modification of LD5.

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References