Editorial

Apnea and Atypical Pseudocholinesterase

Authors: RICHARD A. RINK MD, MUJTABA HUSAIN MD

Abstract

Abstract: A 21 year old man demonstrated neuromuscular paralysis for more than 5 hours following the administration of approximately 150 mg of succinylcholine for an elective tonsillectomy under general anesthesia. Cholinesterase units, dibucaine and fluoride numbers of the patient, his sister and his mother established that the inheritance of the gene for atypical pseudocholinesterase was the dominant factor in this apnea and a similar experience for the sister 9 years earlier. Since both siblings in this report demonstrated atypical pseudocholinesterase, it is likely that these siblings are an example of silent gene inheritance from the father resulting in dominant expression of the maternally inherited atypical gene.

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References