Primary Article

Avascular Necrosis of Bone A Manifestation of Cushings Disease

Authors: KEITH A. PHILLIPS MD, E. PAUL NANCE JR. MD, R. MICHAEL RODRIGUEZ MD, JEREMY J. KAYE MD

Abstract

ABSTRACTCushings disease is endogenous hypercortisolism due to a pituitary adenoma. Although exogenous hypercortisolism is a well known cause of avascular necrosis and although there have been many reports of avascular necrosis associated with endogenous Cushings syndrome, there has only been a single well documented case report associating avascular necrosis of bone with Cushings disease. We report four new cases of avascular necrosis of bone in patients with well documented Cushings disease.

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