Letter to the Editor

Breast Cancer in a Patient with Agnogenic Myeloid Metaplasia

Authors: Zafer Arik, MD, Cigdem Ozkan, MD, Evren Ozdemir, MD, Kadri Altundag, MD

Abstract

To the Editor:


Agnogenic myeloid metaplasia (AMM), also known as chronic idiopathic myelofibrosis or myelofibrosis with myeloid metaplasia, is a clonal disorder of a multipotent hematopoietic progenitor cell of unknown etiology characterized by marrow fibrosis, myeloid metaplasia with extramedullary hematopoiesis, and splenomegaly.1 Secondary myelofibrosis and splenomegaly occur in a variety of benign and malignant disorders, including breast carcinoma.1,2 To our knowledge, breast carcinoma developing years after initial diagnosis of AMM has not been reported in the literature. Herein, we present a patient with breast carcinoma occurring four years after the initial diagnosis of AMM.

This content is limited to qualifying members.

Existing members, please login first

If you have an existing account please login now to access this article or view purchase options.

Purchase only this article ($25)

Create a free account, then purchase this article to download or access it online for 24 hours.

Purchase an SMJ online subscription ($75)

Create a free account, then purchase a subscription to get complete access to all articles for a full year.

Purchase a membership plan (fees vary)

Premium members can access all articles plus recieve many more benefits. View all membership plans and benefit packages.

References

1. Barosi G. Myelofibrosis with myeloid metaplasia: diagnostic definition and prognostic classification for clinical studies and treatment guidelines. J Clin Oncol 1999;17:2954–2970.
 
2. Hoffman R, Ravandi-Kashandi F. Idiopathic Myelofibrosis, in Hoffman R, Benz EJ Jr, Shattil SJ, et al (eds): Hematology: Basic Principles and Practices. Philadelphia, Elsevier Scientific, 2005, ed 4, pp 1255–1257.
 
 
3. Ahmed A, Chang CC. Chronic idiopathic myelofibrosis: clinicopathologic features, pathogenesis, and prognosis [Review]. Arch Pathol Lab Med 2006;130:1133–1143.
 
4. Xiao L, Luxi S, Ying T, et al. Diagnosis of unknown nonhematological tumors by bone marrow biopsy: a retrospective analysis of 10,112 samples. J Cancer Res Clin Oncol 2009;135:687–693.