Primary Article

Clinical Expression of Sickle Cell Anemia in the Newborn

Authors: JANNA ARINA VAN WIJGERDEN MD

Abstract

The clinical records of 14 neonates with hemoglobin S homozygosity were reviewed. The infants were identified through a statewide cord blood testing program in Georgia for abnormal hemoglobins. Nine of the 14 patients had neonatal jaundice, most likely due to hemolysis. In one patient, significant anemia appeared as early as six weeks postnatally. It is suggested that neonatal jaundice may be an early sign of sickle cell anemia. A significant anemia can also develop before 3 months of age even when Hb F levels are usually still rather high.

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References