Invited Commentary

Commentary on Does Melatonin Have Therapeutic Use in Tinnitus?

Authors: Gregory R. Dion, MD, MS


Tinnitus is a common complaint, affecting >16 million adults in the United States.1 It is typically linked to acoustic trauma, head injury, medications, noise, or natural hearing loss. Tinnitus often is more than just an annoyance to patients; it can significantly affect their sleep, concentration, and mood. The economic burden of tinnitus is substantial; one study estimated the societal cost of tinnitus to the Netherlands, a country of <20 million people, was >€6.8 billion.2

This content is limited to qualifying members.

Existing members, please login first.

If you have an existing account please login now to access this article or view your purchase options.

Purchase only this article ($15)

Create a free account, then purchase this article to download or access it online for 24 hours.

Purchase an SMJ online subscription ($75)

Create a free account, then purchase a subscription to get complete access to all articles for a full year.

Purchase a membership plan (fees vary)

Premium members can access all articles plus recieve many more benefits. View all membership plans and benefit packages.


1. Shargorodsky J, Curhan GC, Farwell WR. Prevalence and characteristics of tinnitus among US adults. Am J Med 2010;123:711-718.
2. Maes IH, Cima RF, Vlaeyen JW, et al. Tinnitus: a cost study. Ear Hear 2013;34:508-514.
3. Baguley D, McFerran D, Hall D. Tinnitus. Lancet 2013;382:1600-1607.
4. Youssef D, Merrick L, Tanner M, et al. Does melatonin have therapeutic use in tinnitus? South Med J 2014;107:362-366.
5. Bubenik GA, Blask DE, Brown GM, et al. Prospects of the clinical utilization of melatonin. Biol Signals Recept 1998;7:195-219.
6. Polimeni G, Esposito E, Bevelacqua V, et al. Role of melatonin supplementation in neurodegenerative disorders. Front Biosci (Landmark Ed) 2014;19:429-446.
7. Zhdanova IV, Piotrovskaya VR. Melatonin treatment attenuates symptoms of acute nicotine withdrawal in humans. Pharmacol Biochem Behav 2000;67:131-135.
8. Reiter RJ, Tan DX, Korkmaz A, et al. Drug-mediated ototoxicity and tinnitus: alleviation with melatonin. J Physiol Pharmacol 2011;62:151-157