Cronkhite-Canada Syndrome With Hypothyroidism
Cronkhite-Canada syndrome is a rare, noninherited gastrointestinal polyposis syndrome associated with characteristic ectodermal abnormalities. This report describes a 60-year-old female who was diagnosed with Cronkhite-Canada syndrome with hypothyroidism after presenting with chronic diarrhea, alopecia, intermittent abdominal pain, generalized gastrointestinal polyposis, hyperpigmentation, and nail dystrophy. Endoscopic examination of the stomach and duodenum showed multiple sessile polyps and mucosal erosion associated with evidence of chronic inflammation. Colonoscopy also revealed mucosal edema and diffuse polyposis.
* Cronkhite-Canada syndrome is a rare and noninherited gastrointestinal polyposis syndrome associated with characteristic ectodermal abnormalities.
* This report describes a 60-year-old female who was diagnosed with Cronkhite-Canada syndrome with hypothyroidism.
* Endoscopic examination showed multiple sessile polyps in the stomach, duodenum, and colon.
* Treatment is symptomatic and to effectively improve the patient's diarrhea and dermatologic manifestations.
* The cause and pathogenic features of this syndrome needed to be investigated gradually.
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