Editorial

Fluorodeoxyglucose F 18 Positron Emission Tomography Scanning in Thoracic Disease

Authors: Ruairi J. Fahy, MD, Mark King, MD

Abstract

Positron emission tomography (PET) is based on the observation that tumor cells exhibit high glucose utilization.1 Though not unique to malignant cells, this feature prompted the development of a radiolabeled tagged glucose tracer that can assess tissue metabolism. Fluorodeoxyglucose F 18 (FDG) is the tracer most widely used in clinical practice. Positrons emitted from the tracer release two high-energy photons when they collide with electrons. Detectors record the dual photon emission, and computer software accurately maps their origin. Data can be displayed in individual planes or as a three-dimensional image. Scans are interpreted visually or quantitatively, using what is known as the standardized uptake value (SUV). A value greater than 2.5 is usually considered to indicate malignancy.

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