Abstract

Seventeen patients with a variety of hematologic neoplasms were evaluated for degree of megaloblastic maturation, serum folate, and vitamin B2 levels. There was no correlation between the degree of megaloblastosis and serum folate or B12 abnormalities. There was no clinical response to pharmacologic doses of folc acid or vitamin B12. Patients who responded well to antineoplastic therapy corrected their onemia regardless of initial megaloblastosis, serum folate, or B12 levels. It is concluded that the abnormalities noted are related to the neoplasm and are not clinically significant