Case Report

Myasthenic (Eaton-Lambert) Syndrome Associated With Pulmonary Large-Cell Neuroendocrine Carcinoma

Authors: TANER DEMIRER MD, JOHN RAVITS MD, DAVID ABOULAFIA MD

Abstract

ABSTRACT: A 66-year-old woman presented clinical findings of Eaton-Lambert (myasthenic) syndrome (ELS). Fifteen months later, large-cell pulmonary carcinoma was detected. After systemic chemotherapy and radiotherapy, the tumor regressed and neurologic function improved. Although ELS is usually associated with pulmonary small-cell carcinoma, a minority of tumors are of squamous or glandular differentiation. We believe this is the first case report of ELS associated with large-cell neuroendocrine carcinoma in the English language literature, and it illustrates the importance of an aggressive approach to diagnosis and treatment.

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References