Abstract
Abstract:Plasma cell leukemia (PCL) is a rare plasma cell disorder. It is the leukemic variant of multiple myeloma. A 52-year-old man with an atypical presentation of primary plasma cell leukemia is reported. The patient presented with paraparesis which progressively worsened to paraplegia. MRI of the spine showed an extradural mass causing cord compression and multiple bony erosions from soft tissue masses. Peripheral blood film examination and bone marrow aspiration showed numerous plasmablasts. Atypical cells expressed surface and cytoplasmic lambda light chain on immunochemical studies, surface CD45 and CD38. To our knowledge, primary PCL presenting with progressive paraplegia has not been reported in the literature.
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References
References1. Kyle RA, Maldonado JE, Bayrd ED. Plasma cell leukemia. Report on 17 cases. Arch Intern Med 1974;133:813–818.KyleRA]]MaldonadoJE]]BayrdEDPlasma cell leukemia. Report on 17 cases.Arch Intern Med1974133813-8182. Dimopoulos MA, Palumbo A, Delasalle KB, et al. Primary plasma cell leukaemia. Br J Haematol 1994;88:754–759.DimopoulosMA]]PalumboA]]DelasalleKB&etal;Primary plasma cell leukaemia.Br J Haematol199488754-7593. International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121:749–757.International Myeloma Working GroupCriteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group.Br J Haematol2003121749-7574. Bladé J, Kyle RA. Nonsecretory myeloma, immunoglobulin D myeloma, and plasma cell leukemia. Hematol Oncol Clin North Am 1999;13:1259–1272.BladéJ]]KyleRANonsecretory myeloma, immunoglobulin D myeloma, and plasma cell leukemia.Hematol Oncol Clin North Am1999131259-12725. Pasmantier MW, Azar HA. Extraskeletal spread in multiple plasma cell myeloma. A review of 57 autopsied cases. Cancer 1969;23:167–174.PasmantierMW]]AzarHAExtraskeletal spread in multiple plasma cell myeloma. A review of 57 autopsied cases.Cancer196923167-1746. Benson WJ, Scarffe JH, Todd ID, et al. Spinal-cord compression in myeloma. Br Med J 1979;1:1541–1544.BensonWJ]]ScarffeJH]]ToddID&etal;Spinal-cord compression in myeloma.Br Med J197911541-15447. Panizo C, Rifón J, Rodríguez-Wilhelmi P, et al. Long-term survival in primary plasma cell leukemia after therapy with VAD, autologous blood stem cell transplantation and interferon-alpha. Acta Haematol 1999;101:193–196.PanizoC]]RifónJ]]Rodríguez-WilhelmiP&etal;Long-term survival in primary plasma cell leukemia after therapy with VAD, autologous blood stem cell transplantation and interferon-alpha.Acta Haematol1999101193-1968. Costello R, Sainty D, Bouabdallah R, et al. Primary plasma cell leukemia: a report of 18 cases. Leuk Res 2001;25:103–107.CostelloR]]SaintyD]]BouabdallahR&etal;Primary plasma cell leukemia: a report of 18 cases.Leuk Res200125103-107
