Abstract

Clinical renovascular hypertension is generally associated with a decrease in glomerular filtration rate and renal plasma flow on the involved side. This effect is seen in the experimental preparation and can be influenced by revascularization of the kidney by direct splenic artery implantation into the renal cortex. Two groups of dogs were studied. Three dogs were studied acutely; the renal artery was partially occluded with a Goldblatt clamp and creatinine and para-aminohippurate (PAH) clearance studies done twice. In the second group of dogs, after preliminary nephrectomy, a Goldblatt clamp was applied, time was allowed for hypertension to develop, and the splenic artery was implanted into the renal cortex. In the acute studies, creatinine clearance and PAH clearance decreased by more than 50%. In chronic preparations, creatinine clearance dropped after application of the clamp and hypertension developed, but returned to near normal after implantation of the splenic artery. PAH clearance dropped after application of the clamp but returned to normal after implantation of the splenic artery.