Original Article

Sleep Duration and C-Reactive Protein in US Adults

Authors: Michael R. Richardson, MSH, ACSM EP-C, James R. Churilla, PhD, MPH


Objective: To use gender-stratified logistic regression analysis to examine the associations between elevated C-reactive protein (CRP; >3–10 mg/L) and sleep duration.

Methods: The study sample included male (n = 5033) and female (n = 4917) adult (20 years old and older) participants in the 2007–2010 National Health and Nutrition Examination Survey. Sleep duration was categorized as short (≤6 hours/day), adequate (7–8 hours/day), or long (≥9 hours/day). Logistic regression models were adjusted for age, race, smoking status, physical activity, and waist circumference.

Results: Analysis revealed significantly (P = 0.0151) higher odds of elevated CRP in men reporting ≤6 hours/day of sleep (odds ratio 1.26, 95% confidence interval 1.05–1.52) when compared with a referent group of men reporting 7 to 8 hours/day of sleep. Similar associations were not revealed in women.

Conclusions: Short sleep duration was significantly associated with elevated serum CRP concentration independent of waist circumference and moderate physical activity in men but not in women.

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