Case Report
Splenic Lymphoma With Villous Lymphocytes Diagnosis by Flow Cytometry and Immunocytochemistry
Abstract
ABSTRACTSplenic lymphoma with villous lymphocytes (SLVL) is a recently described low-grade non-Hodgkin's lymphoma diat may be confused with chronic lymphocytic leukemia and hairy cell leukemia. Herein we report a case of SLVL and show how clinical features, cellular morphology, and flow cytometric analysis are used to distinguish among these three disorders. A newly developed immunocytochemical technique that allows detection of tartrate-resistant acid phosphatase on formalin-fixed, paraffin-embedded specimens was useful in refining our diagnosis of SLVL. Establishing the precise diagnosis is important because treatment is different for each of the three chronic lymphoproliferative malignancies.This content is limited to qualifying members.
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