Letter to the Editor

Synchronous Male Carcinoma of the Breast, Exocrine Pancreas, and Prostate

Authors: Alessio G. Morganti, MD, Franco Calista, MD, Samantha Mignogna, MD, Gabriella Macchia, MD, Francesco Deodato, MD, Giovanni Scambia, MD, Arnaldo Carbone, MD

Abstract

To the Editor:


An association between carcinoma of the breast, pancreas, and prostate has been reported.1–3 Epidemiologic studies showed a higher risk of breast, prostate, and pancreatic cancer in families of breast cancer patients4; an increased risk of early onset of pancreatic and prostatic cancer in families with two cases of breast cancer before the age of 505; and a higher incidence of secondary tumors, particularly prostatic tumors in patients with male breast carcinoma.1 To the best of our knowledge, however, there has been no previous report of the synchronous appearance of these three different tumors.

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References

1. Cutuli BF, Lacroze M, Dilhuydy JM, et al. Breast cancer in men: incidence and types of associated previous synchronous and metachronous cancers. Bull Cancer 1992;79:689–696.
 
2. Coard K, McCartney T. Bilateral synchronous carcinoma of the male breast in a patient receiving estrogen therapy for carcinoma of the prostate: cause or coincidence? South Med J 2004;97:308–310.
 
3. Otrock ZK, Mahfouz RA, Salem ZM. Four primary tumors of lung, bladder, prostate, and breast in a male patient. South Med J 2005;98:946–949.
 
4. Tulinius H, Olafsdottir GH, Sigvaldason H, et al. Neoplastic diseases in families of breast cancer patients. J Med Genet 1994;31:618–621.
 
5. Lorenzo Bermejo J, Hemminki K. Risk of cancer at sites other than the breast in Swedish families eligible for BRCA1 or BRCA2 mutation testing. Ann Oncol 2004;15:1834–1841.