The Southern Medical Journal (SMJ) is the official, peer-reviewed journal of the Southern Medical Association. It has a multidisciplinary and inter-professional focus that covers a broad range of topics relevant to physicians and other healthcare specialists.

SMJ // Article

Commentary

The Role of Surgery and 131 I Therapy for Hyperthyroidism in the Etiology of Thyroid Carcinoma

Authors: FUAD S. ASHKAR MD, AUGUST MIALE JR. MD, WILLIAM M. SMOAK III MD, MORTON B. WEINSTEIN MD

Abstract

The occurrence of thyroid carcinoma- following 131I therapy for thyrotoxicosis is unusual; only nine cases are reported to date in the literature. This study reports four patients who developed thyroid carcinoma following surgical treatment for thyrotoxicosis in a series of 48 patients. Chronic stimulation with endogenous thyrotropin (TSH) and long-acting thyroid stimulator (LATS) after surgery may have some etiologic role in this situation. 131 I therapy for hyperthyroidism results in impairment of the reproductive integrity of the thyroid cell, resulting in a high incidence of hypothyroidism and a low incidence of thyroid carcinoma

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