The Southern Medical Journal (SMJ) is the official, peer-reviewed journal of the Southern Medical Association. It has a multidisciplinary and inter-professional focus that covers a broad range of topics relevant to physicians and other healthcare specialists.
SMJ // Article
Primary Article
Treatment of Otitis Media Caused by Hemophilus influenzae: Evaluation of Three Antimicrobial Regimens
Abstract
ABSTRACT: Ninety young children with otitis media, proven by tympanocentesis culture to be due to Hemophilus influenzae, were treated in a prospective double-blind study with one of three antimicrobial regimens: ampicillin, erythromycin ethylsuccinate, or erythromycin ethylsuccinate with concomitant trisulfapyrimidines. Results of efficacy evaluation indicated that the combination was as effective as ampicillin and statistically superior to erythromycin alone. Of the strains of H influenzae identified, 15/9 were typable with 12/9, type b. In vitro sensitivity tests indicated that the strains were sensitive to the antimicrobials studied in clinically attainable levels; however, comparison of individual efficacy ratings with sensitivity results indicated that some children in each treatment group failed to respond as predicted.This content is limited to qualifying members.
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