Issue - Southern Medical Association

Clinical Review

Umbilical Cord Blood Transplantation Providing a Donor for Everyone Needing a Bone Marrow Transplant?

ABSTRACT Background.Bone marrow transplantation (BMT) has been limited in the past by the availability of matched donors for patients. Over the past decade, the use of umbilical cord blood (UCB) as a source of hematopoietic stem cells has revolutionized the field of BMT, providing a source of hematopoietic stem cells…

Primary Article

Experience With Clozapine in a Community Mental Health Care Setting

ABSTRACT Background.Clozapine has been heralded as the first major breakthrough in antipsychotic drug therapy for treatment-resistant schizophrenia in 40 years. This study reports on the experience with clozapine in an outpatient, community mental health care setting. Methods.All clinic patients receiving clozapine during the 4-year period 1992 to 1996 were retrospectively…

Primary Article

Prostate-specific Antigen Values and Their Clinical Significance in Renal Transplant Recipients

ABSTRACT Background.In the diagnosis of prostate cancer, prostate-specific antigen (PSA) is the most clinically useful tumor marker. Its utility in renal transplant patients is unclear. We hypothesized that PSA values might be affected by the renal function, immunosuppression, or proteinuria. Methods.Three hundred four PSA values were measured in 166 patients…

Primary Article

Illicit Alcohol (Moonshine) Consumption in West Alabama Revisited

ABSTRACT Background.Lacy and Wintemitz in 1984 and Pegues in 1991 showed the presence of moonshine-related lead poisoning in Alabama. Methods.This study was a 10-year follow-up to the Lacy and Wintemitz study and used a similar inpatient retrospective chart review methodology. We looked at cases occurring between 1989 and 1992, which…

Current Concepts

An Interdisciplinary Effort to Help Patients With Limited Prescription Drug Benefits Afford Their Medication

ABSTRACT Background.Patients without prescription benefits present a significant challenge to health care providers. The inability of patients to afford medication may serve as a barrier to adherence and may ultimately result in poor patient outcomes. In this report, we describe the system used at a university-based adult internal medicine center…

Primary Article

Rubella Serology in Mentally Retarded Adults

ABSTRACT Background.Rubella and congenital rubella syndrome remain a problem in the United States; institutionalized individuals are at higher risk. We assessed demographic variables and rubella serology in a population of institutionalized adults with mental retardation. Methods.Subjects were 181 institutionalized adults with mental retardation. We reviewed charts to determine patient's age,…

Current Concepts

Escherichia coli and the Hemolytic-uremic Syndrome

ABSTRACT Background.The hemolytic-uremic syndrome (HUS) comprises hemolytic anemia, acute renal failure, and thrombocytopenia. It is the most frequent cause of acute renal failure in children. Methods.This review is based on an extensive overview of the literature dealing with the HUS in children. Results.HUS is the most common cause of acute…

Current Concepts

Review of Cutaneous Lasers and Their Applications

ABSTRACT Background.The use of lasers has assumed an increasingly important role in the treatment of a variety of cutaneous lesions over the past few decades. Because of their effectiveness, physicians from a variety of specialties have incorporated lasers into their practices. Unfortunately, widespread availability of lasers and the public's fascination…

Primary Article

Admission Serum Albumin Level and Length of Hospitalization in Elderly Patients

ABSTRACT Background.We sought to determine whether elderly patients with a serum albumin level <3.4 g&sol;dL on admission to community hospitals have a longer duration of hospitalization than those with an admission serum albumin level ≥3.4 g&sol;dL. Methods.A total of 144 patients, 60 years of age or older, were consecutively admitted…

Primary Article

Prevalence of Hot Flushes During and After Neoadjuvant Hormonal Therapy for Localized Prostate Cancer

ABSTRACT Objectives.We sought to determine the prevalence of hot flushes after neoadjuvant hormonal therapy. Methods.Forty-three patients who received neoadjuvant hormonal therapy before radical prostatectomy were asked to complete a questionnaire regarding hot flushes. Results.Complete information was available for 35 of the 43 patients. No hot flushes were noted in 20&percnt;;…

Case Report

Leg Weakness in Neurosarcoidosis

ABSTRACT&colon; A 22-year-old man had leg weakness and decreased hearing. A diagnosis of neurosarcoidosis was made, based on neuroimaging studies and lymph node biopsy. Posttreatment neuroimaging, in particular magnetic resonance imaging along with clinical course, is useful in monitoring response to therapy.

Case Report

Symptomatic Pulmonary Hyalinizing Granuloma

ABSTRACT&colon; An otherwise healthy 37-year-old man came to the emergency room with leftsided dull chest pain of 4 weeks' duration. Physical examination, laboratory studies, and electrocardiogram were all unremarkable. A chest x-ray film revealed calcined pulmonary nodules. Computed tomography of the chest confirmed bilateral parenchymal cavitary lesions. Via limited thoracotomy,…

Case Report

Blastomycosis as an Etiology of Acute Lung Injury

ABSTRACT&colon; Blastomyces dermatitidis, a dimorphic broad-based budding yeast endemic to the Mississippi River Valley region, is responsible for morbidity in humans via inhalation and dissemination. The response of acute lung injury, which produces an illness with serious morbidity and an approximately 50&percnt; mortality, uncommonly occurs. Diagnosis can be difficult, and…

Case Report

Evidence of Acute Stress Disorder After Diagnosis of Cancer

ABSTRACT&colon; Cancer patients frequently have symptoms of anxiety and depression after diagnosis. Often these symptoms are apparent to the physician. We report the case of a cancer patient who appeared to her physician to be coping relatively well but was actually having psychologic symptoms that met criteria for acute stress…

Case Report

Ulnar Neuropathy Associated With Subdermal Contraceptive Implant

ABSTRACT&colon; Side effects are a common occurrence in the use of subdermal contraceptive implants (Norplant); approximately 70&percnt; to 80&percnt; of women using the device report abnormal uterine bleeding, headaches, acne, mastalgia, nervousness, appetite changes, and weight gain. Local implant site reactions range from 0.4&percnt; to 4.7&percnt;, with pain being the…

Primary Article

Hepatic Amebiasis Among Patients in a Public Teaching Hospital

ABSTRACT&colon; The increase in immigration to the United States is associated with diseases, such as amebiasis, that are endemic to developing countries. We retrospectively reviewed 49 publichospital patients with hepatic amebiasis occurring between 1985 and 1995. Most patients were immigrants (47) from Latin America (43), male (43), and young (mean…

Case Report

Visceral Larva Migrans and the Hypereosinophilia Syndrome

ABSTRACT&colon; This is a case of visceral larva migrans and hypereosinophilia syndrome with persistently elevated white blood cell count despite adequate medical therapy in a 4-year-old boy with leukocytosis and splenomegaly. Medical history included reactive airway disease and geophagia (pica). Serology for Toxocara canis revealed elevated IgG and IgM titers….

Case Report

Simvastatin-Induced Lupus Erythematosus

ABSTRACT&colon; We report the case of a 79-year-old man who had onset of fatigue, myalgia, and pleuritic chest pain 3 months after initiation of therapy with simvastatin. He had signs of pleuropericarditis due to simvastatin-induced lupus erythematosus. This should alert clinicians to this possible adverse effect of simvastatin and other…

Case Report

HIV Seronegativity in an Infant With the Acquired Immunodeficiency Syndrome

ABSTRACT&colon; We report the case of an infant with progressive human immunodeficiency virus (HIV) infection and persistent seronegativity. The child had Pneumocystis carinii pneumonia at 4 months of age and was documented to be HIV-infected by HIV-1 deoxyribonucleic acid (DNA) polymerase chain reaction (PCR), but enzyme-linked immunosorbent assay (ELISA) and…

Abstract

ADVERSE DRUG REACTIONS AMONG THE LEADING CAUSES OF DEATH IN HOSPITALIZED PATIENTS

Our Medical Heritage

Apothecary Shop and Doctor's Office · Old Beaufort-by-the-Sea, North Carolina

Editorial

CREATINE SUPPLEMENTATION&colon; SAFE AS STEAK?

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FECAL OCCULT BLOOD, TO TEST OR NOT TO TEST?

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FOLIC ACID SUPPLEMENTATION, PLASMA H0M0- CYSTEINE, AND ATHEROSCLEROSIS

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LOW CHOLESTEROL LEVELS AND VIOLENCE

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MAMMOGRAPHY&colon; FALSE-POSITIVE RESULTS

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MICROVASCULAR SPASMS AND ANGINA

News Potpourri

News Potpourri

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NONPHARMACOLOGIC MANAGEMENT HYPERTENSION IN OLDER PEOPLE

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ORAL CONTRACEPTIVES AND CARDIOVASCULAR DISEASE

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PASSIVE SMOKING IMPAIRS ELASTICITY OF AORTA

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SAFETY OF DRUGS DURING PREGNANCY