Invited Commentary

Commentary on "pANCA Positivity Predicts Lower Clinical Response to Infliximab Therapy among Patients with IBD"

Authors: Edmund Leung

Abstract

Inflammatory bowel disease (IBD) is a debilitating condition that presents as a spectrum of both gastrointestinal and extraintestinal disorders. The etiology remains unknown, although it is theorized to be immunologically mediated. Despite careful history and physical examination and advances in imaging and endoscopic techniques, differentiating between Crohn disease (CD) and ulcerative colitis (UC) can still be challenging. Many histological diagnoses of indeterminate colitis are eventually reassigned to either CD or UC.1

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References

1. Vermeire S, Peeters M, Rutgeerts P. Diagnostic approach to IBD. Hepatogastroenterology 2000;47:44-48.
 
2. Vermeire S, Van Assche G, Rutgeerts P. C-reactive protein as a marker for inflammatory bowel disease. Inflamm Bowel Dis 2004;10:661-665.
 
3. Nguyen DL, Nguyen ET, Bechtold ML. pANCA positivity predicts lower clinical response to infliximab therapy among patients with IBD. South Med J 2015;108:139-143.
 
4. Esters N, Vermeire S, Joossens S, et al. Serological markers for prediction of response to anti-tumor necrosis factor treatment in Crohn’s disease. Am J Gastroenterol 2002;97:1458-1462.
 
5. Joossens S, Reinisch W, Vermeire S, et al. The value of serologic markers in indeterminate colitis: a prospective follow-up study. Gastroenterology 2002;122:1242-1247.