Issue - Southern Medical Association

Original Article

pANCA Positivity Predicts Lower Clinical Response to Infliximab Therapy among Patients with IBD

Objectives: Several studies have been performed evaluating the role of perinuclear anti-neutrophil cytoplasmic antibodies (pANCA) to predict early clinical response among patients with inflammatory bowel disease (IBD) who are undergoing infliximab therapy. The results of these studies are variable, however, and the effect of pANCA+ as a predictor of clinical…

Original Article

Rural-Urban Differences in HIV Viral Loads and Progression to AIDS among New HIV Cases

Objective: The human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic in the United States has shifted to the South, where an increasing proportion is occurring in rural areas. We sought to gain a better understanding of the affected rural population in this region. Methods: The statewide HIV/AIDS Electronic Reporting System database…

Invited Commentary

Commentary on “Time to Dedifferentiate”

Medical education has continued to evolve since the Flexner report was published more than 100 years ago. Perpetual changes in the healthcare delivery system and societal expectations for high quality in both medical training and practice have led to a reform in medical education. A snapshot of medical education in…

General Information

CME Instructions

Each CME activity should take approximately 1 hour to complete. Each CME activity includes the following: Full text article Article CME information CME test Evaluation Learner-directed phase CME activities within the online journal CME on the Southern Medical Association’s Web site can be accessed in the following ways: Through the…

Original Article

Uveal Melanoma in the First 4 Decades of Life

Objectives: According to reports in the clinical literature, metastatic uveal melanoma in young adults has not been well studied. This article describes the clinical characteristics and natural history of patients who were diagnosed as having uveal melanoma in the first 4 decades of life. Methods: This was a chart review…

Invited Commentary

Commentary on “Religion, Sense of Calling, and the Practice of Medicine: Findings from a National Survey of Primary Care Physicians and Psychiatrists”

How many physicians feel a calling to medicine, and does it matter? In this issue of the Southern Medical Journal, Yoon and colleagues1 augment a small but growing literature on a sense of calling, which suggests both connections with self-efficacy2 and satisfaction in treating certain categories of patients.3 Although previous…

Original Article

Religion, Sense of Calling, and the Practice of Medicine: Findings from a National Survey of Primary Care Physicians and Psychiatrists

Objectives: A sense of calling is a concept with religious and theological roots; however, it is unclear whether contemporary physicians in the United States still embrace this concept in their practice of medicine. This study assesses the association between religious characteristics and endorsing a sense of calling among practicing primary…

Original Article

Vitamin D Deficiency in Pediatric Patients with Cystic Fibrosis: Associated Risk Factors in the Northern United States

Objectives: Cystic fibrosis (CF) is associated with vitamin D deficiency, which can lead to adverse effects including recurrent pulmonary infections and osteoporosis. We longitudinally investigated calcifediol or 25-hydroxyvitamin D (25(OH)D) levels for our pediatric patients with CF based on the time of year as well as vitamin D supplementation dosing…

Perspectives

Time to Dedifferentiate

“One of the mechanisms associated with natural regeneration is dedifferentiation, which involves a terminally differentiated cell reverting back to a less differentiated stage from within its own lineage.”1 “ The only part of the mature mammalian limb that possesses regenerative capabilities is the tips of the digits.”2 After years of…

Review Article

CME Article: Abuse of Medications That Theoretically Are Without Abuse Potential

The potential for abuse of medications that are controlled substances is well known. Abuse of certain noncontrolled prescription drugs and over-the-counter medications also may occur. To some degree, any medication that exerts psychoactive effects may be abused if taken in high enough doses or by means that result in high…

Original Article

Trends in Cigarette Smoking and Obesity in Appalachian Kentucky

Objectives: The southern region of the United States, particularly central and southern Appalachia, has long been identified as an area of health inequities. An updated and more complete understanding of the association among the leading risk factors for such health inequities allows researchers, clinicians, and policymakers to focus their efforts…

Invited Commentary

Commentary on “pANCA Positivity Predicts Lower Clinical Response to Infliximab Therapy among Patients with IBD”

Inflammatory bowel disease (IBD) is a debilitating condition that presents as a spectrum of both gastrointestinal and extraintestinal disorders. The etiology remains unknown, although it is theorized to be immunologically mediated. Despite careful history and physical examination and advances in imaging and endoscopic techniques, differentiating between Crohn disease (CD) and…

Review Article

Rules for Improving Pharmacotherapy in Older Adult Patients: Part 2 (Rules 6-10)

The population of older adult patients in the United States is growing each year. Appropriate pharmacotherapy has allowed many older patients to live longer and maintain healthy lives. Unfortunately, the inappropriate utilization of medications can be harmful to older adult patients. Inappropriate pharmacotherapy may lead to overusing medications and polypharmacy….

Invited Commentary

Commentary on “Trends in Cigarette Smoking Obesity in Appalachian Kentucky”

In this issue of the Southern Medical Journal, Schoenberg and colleagues not only explore the role of smoking and obesity in mortality and morbidity rates in Appalachian Kentucky but they also present a case that further supports the need for analyzing health problems with socio-ecological lenses.1 This is particularly true…