In this issue of the Southern Medical Journal, McFarland et al have published a quite interesting article entitled “Place in Therapy for Liraglutide and Saxagliptin for Type 2 Diabetes.”1 The authors describe and discuss the pharmacology and the utilization for these unique anti-diabetic drugs. Liraglutide, like exenatide, is a glucagon-like…
Objective: The aim of this study was to evaluate atrial conduction abnormalities obtained by Doppler tissue imaging (DTI) and electrocardiogram analysis in Atrial septal aneurysm (ASA) patients. Methods: A total of 30 patients with ASA (11 males/19 females, mean age 29.6 ± 11.3 years) and 25 controls (9 males/16 females,…
Objectives: The consequences of climate change directly threaten human health. Some have argued that, as such, doctors have a special duty to solve climate change. Despite such recommendations, to our knowledge, there has been no previous work documenting physician attitudes on climate change, or the stability of those opinions. Methods:…
Objectives: Compressive ultrasonography (CUS) of the lower limbs is the first choice for identifying deep venous thrombosis (DVT) in patients with symptomatic pulmonary embolism (PE). The aim of this study was to uncover clinical characteristics and CUS findings in patients with proven PE and their correlations with PE extent. Methods:…
Objectives: Manifestations of gastroparesis are heterogeneous and clinical complications are poorly defined. Misconceptions of gastroparesis may be common. The objective was to determine physicians’ perception of gastroparesis and identify areas that need further research and education. Methods: A physician survey was prospectively developed and tested. The survey included questions on…
Background: Computerized Physician Order Entry (CPOE) has the potential to decrease medical errors and improve quality. Our health system plans to implement CPOE in response to the ARRA HITECH Act. Objectives: To determine (A) physicians’ projections of the most important characteristics of a CPOE system that will affect their willingness…
Background: Chemokines and their receptors are clinically important mediators, as the chemokine receptors are expressed on almost all immune cells. They play pivotal roles in pathogenesis of almost all clinical situations including asthma. Correspondingly, MIP-1α (CCL3), MIP-1β (CCL4), and RANTES (CCL5) are among the important chemokines involved in the pathogenesis…
Background: The release of incretin based therapeutic entities has brought the possibility to offer control of the disease by augmenting a natural process in the body that has become deficient with type 2 diabetes. Liraglutide, an incretin mimetic, and saxagliptin, a dipeptidyl peptidase-4 inhibitor, have been approved and introduced to…
Objectives: Differentiation between pulmonary tuberculoma and malignancy by preoperative diagnostic imaging sometimes proves difficult. The purpose of this study is to investigate variable manifestations of pulmonary tuberculoma mimicking lung cancer on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) image and pathologic correlation. Patients and Methods: Twenty-five patients with a high…
Objective: To compare two brief randomized computer-based interventions about perpetration of intimate partner violence (IPV). Methods: The study was a prospective cross-sectional cohort study of patients during randomized 4-hour shifts in an urban hospital-based emergency department setting with an emergency medicine residency. The site is a level 1 trauma center…
To the Editor: Dr Seifi and colleagues contend that a 20-year-old woman had a myocardial infarction after starting atomoxetine.1 It is important to realize that not all ST elevation indicates myocardial ischemia or infarction and neither does a rise in myocardial specific enzymes.
Objectives: Coronary heart disease often presents with ST segment elevation acute myocardial infarction (STEMI). The American College of Cardiology/American Heart Association guidelines stress prompt reperfusion for STEMI. Examining geographic variations in treatment with PPCI (percutaneous primary coronary intervention) and CABG (coronary artery bypass graft) among metropolitan, micropolitan and non-micropolitan rural…
Objectives: To determine whether overweight and obese inpatients are receptive to weight-loss interventions while hospitalized and whether interest in weight-loss intervention correlates with accurate self-perception of weight. Methods: We conducted a cross-sectional survey of overweight and obese patients admitted to the general medicine service at a large urban academic medical…
Diabetes accounts for millions of office visits each year to primary care offices in the United States. Successful care of the patient with type 2 diabetes requires not only focus on glucose management but also on comorbidities such as hypertension, dyslipidemia and obesity which are closely linked to microvascular and…
To the Editor: The entity of fibromyalgia is fairly new and has recently received much publicity as well as criticism. Although the exact pathogenesis is not yet elucidated, there is enough compelling research to suggest a basis for this diagnosis. However, I have recently encountered mixed opinions within the medical…
To the Editor: I read with interest the article entitled “Nephrolithiasis: Evaluation and Management” by Brener et al1 in the February 2011 issue. The authors provide a comprehensive review of the epidemiology, presentation, diagnostic tools, and therapeutic choices of nephrolithiasis. However, there are some points that merit further consideration, especially…
To the Editor: We would like to thank the author for his valuable comments on our paper “Nephrolithiasis: Evaluation and Management.”1 He emphasized the importance of detailed medication history in accurate identification of kidney stone sources. Drug-induced stones comprise 1% to 2% of all kidney stones and occur more often…
To the Editor: Although the diagnosis of perimyocarditis was not and could not be completely ruled out, the clinical presentation, EKG changes, and cardiac enzymes pattern were more consistent with acute myocardial injury (probably secondary to more than one vessel coronary spasm). The patient presented with acute chest pain that…
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