SMJ articles in the category "chemotherapy"

Original Article

Does the Number of Positive Nodes in pN1 Premenopausal HR+/HER2− Breast Cancer Patients with a Low 21-Gene Recurrence Score Predict Chemotherapy Benefit?

Objectives: The RxPONDER trial showed premenopausal patients with pT1-2 N1 hormone receptor-positive (HR+)/HER2− breast cancer benefit from chemotherapy regardless of 21-gene recurrence score (RS), but it did not analyze whether the number of positive lymph nodes (+LNs) was correlative of outcomes. Our study sought to evaluate whether the number of…

Posted in: breast cancer 44 chemotherapy 15 premenopausal 2

Original Article

Risk, Outcomes, and Predictors of Clostridium difficile Infection in Lymphoma: A Nationwide Study

Objective: The risk of Clostridium difficile infection (CDI) has not been well studied in patients with lymphoma. We thus sought to determine the risk of CDI in hospitalizations with lymphoma along with its trend, outcomes, and predictors using a large database. Methods: Hospital discharge data from the Nationwide Inpatient Sample…

Posted in: chemotherapy 15 Clostridium difficile 10 lymphoma 14

Review Article

Treatment of the Pregnant Patient with Breast Cancer

Pregnancy-associated breast cancer is defined as invasive breast cancer diagnosed during gestation, within 1 year postpartum, or during lactation. Of particular interest is the treatment of invasive breast cancer during gestation; standard treatment protocols must take into account the health of the fetus. This article reviews the literature and emerging…

Posted in: breast cancer 44 chemotherapy 15 gestational age 2 postpartum 6 Special Issue 75

Original Article

Quality of Life of Patients with Squamous Cell Carcinoma of the Head and Neck Receiving High-Dose Cisplatin Chemotherapy and Radiotherapy

Objectives: The aim of this study was to evaluate the quality of life (QOL) of patients with squamous cell carcinoma of the head and neck before and during treatment with high-dose cisplatin and radiotherapy. Methods: This was an observational and longitudinal prospective study conducted from June 2011 to March 2013…

Posted in: chemotherapy 15 cisplatin 2 patient safety 24 Quality Health Care 17 quality of life 11 radiotherapy 6 Special Issue 75

Review Article

Risk Assessment and Management of Anthracycline and HER2 Receptor Inhibitor-Induced Cardiomyopathy

With the advent and increased use of chemotherapeutic agents and radiation therapy, cancer survival rates have increased. With increased survival, both acute and chronic cardiotoxic adverse effects have emerged. The growing need for managing the treatment of individuals with chemotherapy-induced cardiotoxicity has led to the formation of cardio-oncology programs throughout…

Posted in: cardiomyopathy 10 cardiotoxicity 4 chemotherapy 15 oncology 2

Review

Prediction of Anthracycline-Induced Left Ventricular Dysfunction by Cardiac Troponins

Evidence suggests prognostic utility of troponin (Tn) serum concentrations for a variety of conditions. We sought to determine whether elevated concentrations early after anthracycline chemotherapy predict the development of left ventricular systolic dysfunction in adult patients with cancer. PubMed/MEDLINE searches identified original reports that assessed cardiac TnI or TnT within…

Posted in: chemotherapy 15 heart failure 20 troponin 8

Case Report

Hemorrhagic Tamponade Due to Cardiac Angiosarcoma

Prognosis of angiosarcoma, the most common primary malignant cardiac tumor, is very poor. An early detection and treatment may extend survival beyond one year. Newer imaging modalities, including magnetic resonance imaging (MRI), play an important role in the evaluation of cardiac masses. The case of a man admitted to the…

Posted in: angiosarcoma 3 chemotherapy 15 hemorrhagic 2 imaging 5 tamponade 2

Expired CME Article

Antineoplastic Agent-Associated Serpentine Supravenous Hyperpigmentation: Superficial Venous System Hyperpigmentation Following Intravenous Chemotherapy

Purpose: To review the clinical characteristics and associated antineoplastic agents in patients who developed hyperpigmentation of the superficial venous system after chemotherapy. Background: Serpentine supravenous hyperpigmentation was the term coined by Hrushesky to describe increased pigmentation of the skin immediately overlying the venous network used for intravenous infusion of 5-fluorouracil….

Posted in: chemotherapy 15

Case Report

A Rare Case of Aplastic Anemia Caused by Temozolomide

Abstract:A 65-year-old female patient with glioblastoma multiforme (GBM) developed aplastic anemia following treatment with temozolomide. Following her diagnosis of GBM, the patient received standard treatment with surgery, concomitant radiation therapy and temozolomide followed by adjuvant temozolomide. On day 14 of her adjuvant treatment, she developed profound fatigue and spontaneous bruising…

Posted in: chemotherapy 15 toxicity 10

Case Report

Postchemotherapy Hyperammonemic Encephalopathy Emulating Ornithine Transcarbamoylase (OTC) Deficiency

A young patient with hepatocellular carcinoma receiving chemotherapy presented with encephalopathy. Evaluation of the patient revealed a metabolic profile consistent with ornithine transcarbamoylase (OTC) deficiency, an inherited disorder of the urea cycle. The evaluation yielded a plasma amino acid analysis consistent with OTC deficiency. However, genetic analysis did not reveal…

Posted in: chemotherapy 15 hepatocellular carcinoma 3

Expired CME Article

Malaria Primer for Clinicians in the United States

Though low, the incidence of malaria in the United States is not insignificant and can be the source of infection in febrile travelers returning from endemic areas. Clinicians practicing in the United States must have a basic understanding of the malaria life cycle and its treatments to properly diagnose and…

Posted in: chemotherapy 15 human immunodeficiency virus 23 malaria 3

Review Article

Extrapulmonary Small Cell Carcinoma

This article reviews the recent literature on extrapulmonary small cell carcinomas. Until now, only four cases have been published in the English literature, two of those in the Southern Medical Journal. Sharing the information on diagnosis and treatment of these cases is important for better understanding and treatment of these…

Posted in: chemotherapy 15 small-cell carcinoma 2

Case Report

Successful Treatment of Head and Neck Cancer Involving the Prevertebral Fascia

Chemotherapy with radiation has become more popular than radiotherapy alone for patients with locally advanced head and neck cancer because of the successful results associated with it. We report the case of a 67-year-old man with hypopharyngeal cancer invading the prevertebral fascia who became free of disease after chemoradiation. This…

Posted in: chemotherapy 15 radiotherapy 6

Case Report

Topotecan-induced Bronchiolitis

Topotecan HCl is an antitumor drug exhibiting topoisomerase I-inhibitory activity. Topotecan is used in the treatment of metastatic carcinoma of the ovary and as second-line treatment of small-cell lung cancer. Reported dose-limiting adverse reactions to topotecan are primarily hematologic in nature. To date, only one other case of lung toxicity…

Posted in: bronchiolitis 2 chemotherapy 15 lung 7

Case Report

Recurrent Bilateral Spontaneous Pneumothorax Complicating Chemotherapy for Metastatic Sarcoma

We present the case of a 63-year-old woman with metastatic, high-grade pleomorphic sarcoma who had recurrent, bilateral pneumothorax while on a regimen of doxorubicin and dacarbazine. We postulate that her doxorubicin-based chemotherapy induced rapid cell lysis and necrosis of peripherally located, metastatic pulmonary nodules, leading to the pneumothoraces. Other potential…

Posted in: chemotherapy 15 doxorubicin 2 pneumothorax 5
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