SMJ articles in the category "toxicity"

Original Article

Less Toxic Chemotherapy in Locally Advanced Breast Cancer

Objectives: Preoperative chemotherapy produces tumor shrinkage in most patients with locally advanced breast cancer, including some pathological complete responses (pCRs). We attempted this using a much less toxic sequential regimen, given with concurrent bevacizumab. Methods: Patients with locally advanced breast cancer received 3 intravenous doses each of preoperative sequential liposome…

Posted in: cardiotoxicity 4 toxicity 10

Review Article

E-Cigarette Toxicity?

Abstract: Tobacco smoking is the most preventable cause of morbidity and mortality. In just a few short years, electronic cigarettes (e-cigarettes) have become increasingly popular, especially for younger individuals. Many people believe that e-cigarettes are safe. The inhaled aerosols of e-cigarettes contain numerous potential toxicities, some of which could be…

Posted in: e-cigarettes 2 electronic cigarettes 2 toxicity 10

Case Report

Acute Lithium Intoxication: Properly Directing an Index of Suspicion

Lithium is known for its efficacy and toxicity. Toxic effects have been characterized even with therapeutic levels. Most physicians will at some point be faced with a patient with altered mental status and no records of his or her history. The differential diagnosis of altered mental status is long, and…

Posted in: altered mental status 4 lithium 5 toxicity 10

Case Report

A Rare Case of Aplastic Anemia Caused by Temozolomide

Abstract:A 65-year-old female patient with glioblastoma multiforme (GBM) developed aplastic anemia following treatment with temozolomide. Following her diagnosis of GBM, the patient received standard treatment with surgery, concomitant radiation therapy and temozolomide followed by adjuvant temozolomide. On day 14 of her adjuvant treatment, she developed profound fatigue and spontaneous bruising…

Posted in: chemotherapy 15 toxicity 10

Original Article

Colchicine Exposures: The Texas Experience

Objectives: Colchicine is a relatively uncommon toxin, but is known to precipitate severe multiorgan failure in overdose. Little is known about exposure patterns and outcomes in cases of colchicine ingestion. Our goal was to add to toxicologic knowledge through a database review and descriptive study of colchicine exposures. Methods: Texas…

Posted in: colchicine 2 outcomes 19 toxicity 10

Case Report

Omeprazole-associated Digoxin Toxicity

Omeprazole is a commonly prescribed inhibitor of the gastric proton pump and has numerous indications in the treatment of gastrointestinal diseases. It is primarily metabolized through the CYP2C19 enzyme, a member of the P450 mixed-function oxidase group, although a minor pathway of metabolism is through CYP3A4, another P450 enzyme. Digoxin…

Posted in: interaction 2 omeprazole 2 toxicity 10

Case Report

Camphor Ingestion in a 10-year-old Male

A 10-year-old male with a history of oppositional defiant disorder and attention deficit disorder suffered from mental status changes, nausea, vomiting and tremulousness after intentional ingestion of three over-the-counter cold remedy transdermal patches. Each patch contained approximately 100 mg of camphor. While in the hospital, the patient was treated supportively,…

Posted in: ingestion 3 Pediatric 12 toxicity 10

Case Report

Oxycodone Accumulation in a Hemodialysis Patient

Oxycodone and oxycodone-containing analgesics are often used for the relief of pain. In the presence of renal dysfunction, the half-life of oxycodone and metabolites can be prolonged. We describe the case of a 41-year-old chronic hemodialysis patient who received multiple doses of oxycodone/acetaminophen resulting in accumulation of the medication and…

Posted in: hemodialysis 9 opioids 10 renal failure 10 toxicity 10

Review Article

Acetaminophen Overdose in Pregnancy

Acetaminophen (APAP) is the most common drug overdose in pregnancy. Available data regarding APAP overdose in pregnancy is limited to case reports and a small prospective case series. APAP has been demonstrated to cross the placenta and in toxic doses may harm the fetal and maternal hepatocytes. Fetal hepatocytes metabolize…

Posted in: overdose 3 pregnancy 48 toxicity 10

Case Report

Fatal Hypermagnesemia Caused by an Epsom Salt Enema: A Case Illustration

The authors describe a case of fatal hypermagnesemia caused by an Epsom salt enema. A 7-year-old male presented with cardiac arrest and was found to have a serum magnesium level of 41.2 mg/dL (33.9 mEq/L) after having received an Epsom salt enema earlier that day. The medical history of Epsom…

Posted in: children 22 death 2 toxicity 10
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