Kulchitsky cells represent the cells of origin of small cell lung cancer (SCLC). They display an antigenic makeup characteristic of both the neural crest and epithelium and have been shown to secrete both polypeptide hormones and enzymes. The coexistence of two or more (concomitant or sequential) paraneoplastic endocrine syndromes is…
Acquired hemophilia is a severe hemorrhagic diathesis characterized by the emergence of anti-factor VIII inhibiting antibodies. It is rarely seen in certain types of cancers as a paraneoplastic syndrome. The case of a 73-year-old patient who developed acquired hemophilia during the course of treatment for a gastrointestinal stromal tumor is…
Penile cancer is very rare in North America and Europe, as compared with the rest of the world. Squamous cell carcinoma (SCC) accounts for more than 95% of the cancer type. Paraneoplastic syndrome (PNS), a clinical syndrome of nonmetastatic systemic effects that occurs in patients with malignant disease, is often…
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