Review Article

Efficacy and Central Nervous System Impairment of Newer-generation Prescription Antihistamines in Seasonal Allergic Rhinitis

Abstract:Allergic rhinitis is a highly prevalent disorder and oral antihistamines are often used to manage patient symptoms. Older-generation antihistamines, such as diphenhydramine and chlorpheniramine, are effective at relieving the symptoms of seasonal allergic rhinitis (SAR); however, they are associated with adverse events, including sedation and impairment, at, or above, the…