Case Report

Fatal Reactive Hemophagocytosis Related to Disseminated Histoplasmosis with Endocarditis: An Unusual Case Diagnosed at Autopsy

Reactive hemophagocytic syndrome (RHS) is an uncommon life-threatening disorder. It is believed to be caused by widespread non-neoplastic proliferation and inappropriate activation of mature macrophages, resulting in excessive cytokine activation which leads to hematophagocytosis by cells of the macrophage-monocyte lineage and multiorgan dysfunction. RHS may be associated with infections caused…