Original Article

Effect of Sildenafil Citrate on Postprandial Gallbladder Motility

Objective: Sildenafil stimulates the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway through inhibition of type 5 phosphodiesterase. NO-cGMP pathway causes smooth muscle relaxation. The aim of this study is to evaluate the effects of sildenafil on gallbladder motility. Methods: Twenty healthy male volunteers (21–35 years old) participated in this randomized, double…