SMJ articles in the category "pulmonary vascular disease"

Review Article

Pulmonary Arterial Hypertension: Evaluation and Management

Pulmonary arterial hypertension (PAH), a rare disease involving the pulmonary vascular circuit, is defined as an elevation in pulmonary arterial pressures and is characterized by symptoms of dyspnea, chest pain, and syncope. If left untreated, the disease carries a high mortality rate, with the most common cause of death being…

Posted in: endothelin 2 pulmonary hypertension 12 pulmonary vascular disease 2

Case Report

Long-term Results After Addition of Sildenafil in Idiopathic PAH Patients on Bosentan

Idiopathic pulmonary arterial hypertension is a disease involving small muscular pulmonary arteries and arterioles. Treatment with prostacyclin analogs and endothelin receptor antagonists is the cornerstone of therapy in these patients. Recent evidence suggests that phosphodiesterase-5 inhibitors such as sildenafil may improve functional capacity and hemodynamics in patients with pulmonary arterial…

Posted in: endothelin 2 pulmonary hypertension 12 pulmonary vascular disease 2 sildenafil 2
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