Case Report

Topotecan-induced Bronchiolitis

Topotecan HCl is an antitumor drug exhibiting topoisomerase I-inhibitory activity. Topotecan is used in the treatment of metastatic carcinoma of the ovary and as second-line treatment of small-cell lung cancer. Reported dose-limiting adverse reactions to topotecan are primarily hematologic in nature. To date, only one other case of lung toxicity…