Original Article

Prescriptions for a Toxic Combination: Use of Methotrexate Plus Trimethoprim-Sulfamethoxazole in the United States

Objectives: To determine the frequency of using the potentially toxic combination of methotrexate and trimethoprim-sulfamethoxazole (TMP-SMX) in outpatient practice in the United States. Methods: Data from the National Ambulatory Medical Care Survey for 1993–2010 were used to assess the frequency of using methotrexate with TMP-SMX and associated physician specialties and…

Posted in: acute lymphoblastic leukemia 3 Adverse event 2 drug interaction 2 polypharmacy 3

Original Article

Analysis of Diagnostic Error in Paid Malpractice Claims with Substandard Care in a Large Healthcare System

Objective: Although claims databases are not representative of all care delivery, their predisposition toward serious unintended injury can complement resource-intensive chart reviews and guide patient safety initiatives. Materials and Methods: Non-Veterans Health Administration (VA) practitioners reviewed 1,949 VA malpractice claims paid during fiscal years 1998 through 2003. The portion associated…

Posted in: Adverse event 2 liability 2 malpractice 3 medical error 2
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