Review Article

CME Article: Management of Sickle Cell Disease in Children

Sickle cell disease (SCD) is a heterogeneous inherited disorder of hemoglobin that causes chronicm hemolytic anemia, vaso-occlusion, and endothelial dysfunction. These physiologic derangements often lead to multiorgan damage in infancy and throughout childhood. The most common types of SCD are homozygous hemoglobin S (HbSS disease), hemoglobin SC disease, and sickle…