Original Article
Efficacy and Safety of Direct Oral Anticoagulants Compared to Warfarin in Patients with Cirrhosis and Splanchnic Vein Thrombosis
Objective: The incidence of splanchnic vein thrombosis (SVT) is reported to be
SMJ articles in the category "Warfarin"
Review Article
Pharmacologic Agents Used to Reverse the Anticoagulant Effect of Common Anticoagulants
Numerous oral and parenteral anticoagulant drugs are now available for clinical use. Understanding the precise pharmacologic properties of each anticoagulant is imperative for those practitioners who prescribe these drugs, including knowing the current recommendations for reversing the anticoagulant effect of each anticoagulant. This review provides a brief description of the…
Review Article
Secondary Stroke Prevention in Nonvalvular Atrial Fibrillation
Approximately 750,000 US adults per year experience a stroke. On average, the annual risk for future ischemic stroke (secondary stroke) after an initial ischemic stroke or transient ischemic attack is approximately 3% to 4%. Cardioembolic strokes account for 20% to 25% of all strokes, with nonvalvular atrial fibrillation (NVAF) considered…
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cardioembolic stroke 2 Warfarin 10
Review Article
Effect of Body Weight on Dose of Vitamin K Antagonists
Objectives: Numerous factors are well documented to affect the response to vitamin K antagonists (VKA), including dietary vitamin K, other drugs, age, pharmacogenetics, and disease states. Body weight is perhaps not as well known as a variable affecting VKA dose. Our aim was to review the literature regarding body weight…
Review
Comparing New Anticoagulants
For years, the pharmaceutical industry has been trying to find a safe and effective drug to replace warfarin. Although warfarin is an effective anticoagulant, its pharmacology, adverse effects, and risk profiles dictate that patients taking this medication must be monitored judiciously. The US Food and Drug Administration has approved two…
Case Report
Warfarin-Induced Skin Necrosis
There is a lack of guidelines regarding the selection of patients who need intravenous heparin, duration of intravenous heparin, and future use of warfarin in prevention and treatment of warfarin-induced skin necrosis. This case report emphasizes the challenges in dealing with vitamin K antagonists (VKA) therapy.
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Atrial Fibrillation 13 Warfarin 10
Original Article
Impact of Preinjury Anticoagulation in Patients with Traumatic Brain Injury
Introduction:This study was undertaken to examine the impact of various anticoagulation agents in head injury patients.Methods:The medical records and trauma registry were used to analyze the data. All adult trauma patients using aspirin, clopidogrel bisulfate (Plavix®), warfarin (Coumadin®), or heparin and admitted to the hospital with computed tomography (CT) scan…
Case Report
Interaction between Warfarin and Levofloxacin: Case Series
Warfarin is the most widely used oral anticoagulant and is indicated for many clinical conditions. Levofloxacin, a fluoroquinolone, is one of the most commonly prescribed antibiotics in clinical practice and is effective against Gram-positive, Gram-negative, and atypical bacteria. While small prospective studies have not revealed any significant drug-drug interaction between…
Review Article
Preventing Warfarin-related Bleeding
Warfarin is one of the most common anticoagulants in current use. It maintains a narrow therapeutic index resulting in a significant amount of bleeding. Changes in concomitant medication use and acute illnesses are common causes of overanticoagulation. Monitoring regimens based on patient characteristics and the intensity and duration of anticoagulant…
Original Article
Clinical Correlation Between Effective Anticoagulants and Risk of Stroke: Are We Using Evidence-based Strategies?
Objectives: Despite evidence supporting anticoagulant use in atrial fibrillation, this modality is not fully utilized. Methods: Retrospective chart review of 297 patients with nonvalvular atrial fibrillation between 1997 to 2000. 124 patients received warfarin and 166 did not; 91 patients suffered stroke. Results: Age (P = 0.232) and gender (P…
