Case Report

Successful Utilization of Aliskiren, a Direct Renin Inhibitor in Bartter Syndrome

Abstract:Bartter syndrome is traditionally treated with large doses of oral potassium with or without suppression of the renin-angiotensin system. Since plasma renin activity is invariably elevated in Bartter syndrome, the availability of the direct renin inhibitor aliskiren should lead to the ability to maintain potassium levels without utilizing large doses…

Posted in: aliskiren 2 hypokalemia 4

Case Report

Aliskiren-Induced QT Interval Prolongation

Abstract:Aliskiren gained FDA approval for the treatment of hypertension in 2007. It is the first approved pharmaceutical to manage hypertension by direct renin inhibition. With the introduction of novel drugs and mechanisms of action comes the challenge of monitoring for new unreported adverse events. The side effect profile for aliskiren…

Posted in: aliskiren 2 QT prolongation 2 side effect 4
SMA Menu