SMJ articles in the category "sarcoidosis"

Original Article

Role of Transbronchial Needle Aspiration (Conventional and EBUS Guided) in the Diagnosis of Histoplasmosis in Patients Presenting with Mediastinal Lymphadenopathy

Objectives: The superior performance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis and staging of malignancy has been demonstrated, with some investigators suggesting the same for sarcoidosis. The role of EBUS-TBNA in the diagnosis of histoplasmosis is not clear, however. In this study we estimate the diagnostic yield…

Posted in: endobronchial ultrasound-guided transbronchial needle aspiration 3 histoplasmosis 3 mediastinal lymphadenopathy 2 sarcoidosis 15

Original Article

Use of Pulmonary Arterial Hypertension-Specific Therapy in Non-WHO Group I Pulmonary Hypertension

Objectives: The development of pulmonary hypertension (PH) in non–World Health Organization group I PH adversely affects exercise capacity. It is unclear whether pulmonary artery hypertension (PAH)–specific drugs improve pulmonary hemodynamics and exercise capacity in such patients. Methods: We performed a retrospective chart review of consecutive patients with non–World Health Organization…

Posted in: chronic obstructive pulmonary disease 10 obstructive sleep apnea 7 pulmonary hypertension 12 sarcoidosis 15 therapy 6

Original Article

Impact of Tracheal Mucosa Involvement on Clinical Characteristics of Sarcoidosis

Objectives: To investigate the impact of tracheal mucosa involvement on the clinical features of sarcoidosis. Methods: The clinical data of sarcoidosis patients with (Group A, n = 26) and without (Group B, n = 61) tracheal mucosa involvement were evaluated retrospectively. Results: The proportion of patients suffering from cough in…

Posted in: clinical features 2 lesion 2 sarcoidosis 15

Original Article

Clinical Manifestations, Radiographic Findings, Treatment Options, and Outcome in Sarcoidosis Patients with Upper Respiratory Tract Involvement

Background: Sarcoidosis of the upper respiratory tract (SURT) is an underappreciated manifestation of sarcoidosis. We described the clinicoradiological findings, methods of treatment, and outcomes of 68 patients with SURT seen in our clinic over a 7-year period. Methods: This was a retrospective study. A Case Control Etiology of Sarcoidosis Study…

Posted in: larynx 2 outcome 13 sarcoidosis 15

Case Report

Hepatopulmonary Syndrome and Liver Sarcoidosis: A Tale of Two Diseases

Abstract:Hepatopulmonary syndrome (HSP) is characterized by the triad of advanced liver disease, arterial hypoxemia, and intrapulmonary vascular dilatation. Most cases of HSP are associated with cirrhotic portal hypertension; however, it has also been reported in acute liver failure patients. An estimated prevalence of HPS in patients with chronic liver disease…

Posted in: cirrhosis 9 hepatopulmonary syndrome 2 sarcoidosis 15

Case Report

Simultaneous Adrenal Pheochromocytoma and Sarcoidosis

Abstract:A 48-year-old man presented for evaluation of general weakness. Because he had a history of excessive alcohol use, an abdominal computed tomography scan was obtained, which revealed a left adrenal mass. Hormonal evaluation showed elevated levels of urinary catecholamines. Bilateral hilar lymphadenopathy was detected on a chest radiograph. The suspected…

Posted in: adrenal incidentaloma 2 pheochromocytoma 6 sarcoidosis 15

Original Article

Analysis of HLA Antigens in Turkish Sarcoidosis Patients

Background: Sarcoidosis is a systemic granulomatous disorder associated with high CD4+cell activity, without any detectable pathogen. Clustering in families occurs, and the existence of a genetic predisposition to sarcoidosis is widely accepted. There are differences among different ethnic groups. Methods: We studied HLA polymorphisms in 64 Turkish patients with biopsy…

Posted in: sarcoidosis 15

Case Report

Sarcoidosis Presenting as Intrascrotal Mass: Case Report and Review

Abstract:Sarcoidosis is a multisystemic disease that usually involves the lungs and lymph nodes, but almost any organ can be involved. Genitourinary involvement with sarcoidosis is extremely rare. We report the case of a 30-year-old African-American male who presented with a right-sided intrascrotal mass and diffuse lymphadenopathy. On further workup, he…

Posted in: genitourinary sarcoidosis 2 noncaseating granulomas 2 sarcoidosis 15

Case Report

Multiple Venous Thromboses in a Young Man with Sarcoidosis: Is There a Relation Between Sarcoidosis and Venous Thrombosis?

Abstract:We describe the case of a 33-year-old African-American male who presented with multiple deep venous thromboses of the upper and lower extremities. Hypercoagulable workup was unrevealing. A chest x-ray showed bilateral hilar lymph node enlargement. Mediastinoscopy with hilar lymph node biopsy was performed. Lymph node histopathologic examination showed noncaseating granulomas….

Posted in: sarcoidosis 15

Case Report

Eosinophilic Pleural Effusion, Peripheral Eosinophilia, Pleural Thickening, and Hepatosplenomegaly in Sarcoidosis

In this atypical case of sarcoidosis with an unusual combination of clinical and laboratory findings, a 32-year-old male presented with a 3-month history of thoracic pain complicated with dyspnea. Laboratory tests, chest radiography, and CT scans of the chest and abdomen revealed eosinophilia of pleural effusion and blood, pleural thickening,…

Posted in: eosinophilia 4 pleura 3 sarcoidosis 15

Case Report

Sarcoidosis Mimicking Disseminated Testicular Cancer

Sarcoidosis rarely involves the genitourinary system or the spinal cord. This report describes a case of sarcoidosis with a scrotal mass, a mass compressing the spinal cord, and lesions in the liver and spleen. This case illustrates an uncommon manifestation of sarcoidosis, which may mimic disseminated testicular cancer. Key Points…

Posted in: genitourinary sarcoidosis 2 neurosarcoidosis 2 sarcoidosis 15

Case Report

Pulmonary Sarcoidosis Presenting with Acute Respiratory Failure

This is a case report of pulmonary sarcoidosis presenting with acute respiratory failure. A 33-year-old black man presented with 4 days of headache and fever. He had subsequent development of respiratory failure on the seventh hospital day. Workup showed high serum angiotensin-converting enzyme and increased pulmonary parenchymal uptake of gallium….

Posted in: sarcoidosis 15

Case Report

Renal Failure and Hypercalcemia as Initial Manifestations of Extrapulmonary Sarcoidosis

Sarcoidosis is a granulomatous, multisystem disease. Rarely, sarcoidosis may present with both renal failure and hypercalcemia. A 27-year-old black man presented with severe abdominal pain and renal failure. A kidney biopsy demonstrated features of both interstitial nephritis and membranous glomerulopathy thought to be secondary to nonsteroidal anti-inflammatory drugs. His renal…

Posted in: hypercalcemia 10 renal failure 10 sarcoidosis 15

Case Report

Coexistence of Sarcoidosis and Malignancy

In 1974, Brincker and Wilbek noted a statistically significant increase of malignant tumors among sarcoid patients and speculated that immunologic deficiencies stemming from sarcoidosis may predispose such patients to malignancy. In this article, we describe three additional cases of sarcoidosis and coexisting malignancy. The temporal presentation, radiographic features, and histologic…

Posted in: lymphoma 14 sarcoidosis 15

Case Report

Pleural Effusion Caused by Trapped Lung

We report a case of pleural effusion from trapped lung secondary to sarcoidosis. The patient presented with dyspnea, right pleural effusion, left and right upper-lobe infiltrate and a widened mediastinum. The pleural effusion and dyspnea failed to respond to a course of oral corticosteroids but was relieved by decortication with…

Posted in: dyspnea 6 pleural effusion 9 sarcoidosis 15 thoracotomy 4
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