SMJ articles in the category "vancomycin"

Original Article

Incidence and Predictors of Vancomycin-Associated Nephrotoxicity

Objectives: Earlier studies reported a low incidence of vancomycin-associated nephrotoxicity (VAN); however, recent studies have reported higher incidences exceeding 30%. Predictors of nephrotoxicity are not well defined. In this study we aimed to better estimate the incidence and evaluate predictors of VAN in a cohort of patients predominated by long…

Posted in: Acute kidney injury 5 vancomycin 6

Original Article

Vancomycin MIC Susceptibility Testing of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Isolates: A Comparison Between Etest® and an Automated Testing Method

Background: Vancomycin treatment failures and increased mortality have been reported in methicillin-resistant Staphylococcus aureus (MRSA) isolates with minimum inhibitory concentrations (MICs) >1 μg/mL. Most of this data utilized manual testing to determine the MIC. Recent vancomycin treatment guidelines do not specify the optimal testing method to define the MIC. Methods:…

Posted in: MRSA 3 vancomycin 6

Review Article

Vancomycin: Understanding Its Past and Preserving Its Future

The increase in vancomycin use in the 1980s to treat antibiotic-associated colitis and methicillin-resistant Staphylococcus aureus (MRSA) is largely responsible for the appearance of vancomycin-resistant enterococcus, which in turn spawned isolated cases of vancomycin-resistant S. aureus. Perhaps most worrisome to clinicians are strains of MRSA that are heteroresistant to vancomycin;…

Posted in: daptomycin 2 MRSA 3 vancomycin 6

Case Report

Significant Absorption of Oral Vancomycin in a Patient with Clostridium difficile Colitis and Normal Renal Function

Orally-administered vancomycin is poorly absorbed in most patients, usually producing minimal or subtherapeutic serum concentrations. Bowel inflammation may enhance absorption of oral vancomycin, particularly in those with renal failure. A 77-year-old female with Clostridium difficile (C difficile) colitis and normal renal function was treated with high doses of oral vancomycin…

Posted in: vancomycin 6

Original Article

Evaluation of the Efficacy and Safety of Outpatient Parenteral Antimicrobial Therapy for Infections With Methicillin-sensitive Staphylococcus aureus

Objectives: As increasing numbers of patients are being treated with outpatient parenteral antimicrobial therapy (OPAT), it becomes ever more important to ascertain the risks and benefits of such treatment for patients. Methods: We conducted a retrospective analysis of 1,515 patients with methicillin-sensitive Staphylococcus aureus infections who were treated with outpatient…

Posted in: Staphylococcus aureus 14 vancomycin 6

Case Report

Vancomycin Therapy and the Progression of Methicillin-resistant Staphylococcus aureus Vertebral Osteomyelitis

Vancomycin therapy is the standard treatment for methicillin-resistant Staphylococcus aureus (MRSA), the most common cause of vertebral osteomyelitis, an increasingly frequent complication of nosocomial bacteremia. We report five recent cases suggesting that, while giving the appearance of success by conventional clinical and laboratory criteria (eg, resolution of fever and leukocytosis),…

Posted in: Staphylococcus aureus 14 vancomycin 6 vertebral osteomyelitis 6
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