SMJ articles in the category "diarrhea"

Original Article

Flexible Sigmoidoscopy Rather than Colonoscopy Is Adequate for the Diagnosis of Ipilimumab-Associated Colitis

Objectives: Treatment with ipilimumab, a cytotoxic T lymphocyte antigen-4 approved for metastatic melanoma can result in clinically significant immune-mediated drug injury in the form of colitis. Timely diagnosis and response are essential for optimal management. The aims of our study were to determine the percentage of our patients with ipilimumab-associated…

Posted in: colonoscopy 24 diarrhea 10

Review Article

Varied Clinical Manifestations of Amebic Colitis

Invasive amebiasis is common worldwide, but infrequently observed in the United States. It is associated with considerable morbidity in patients residing in or traveling to endemic areas. We review the clinical and endoscopic manifestations of amebic colitis to alert physicians to the varied clinical manifestations of this potentially life-threatening disease….

Posted in: amebiasis 4 amebic liver abscess 2 colonoscopy 24 diarrhea 10 hematochezia 2

Review

Diagnosing Irritable Bowel Syndrome: A Changing Clinical Paradigm

Rather than being a diagnosis of exclusion, irritable bowel syndrome (IBS) is a diagnosis that can be identified by symptom-based criteria. The collection of these criteria by a meticulous history can be enhanced by using various tools. Once a positive diagnosis is made, using clinical criteria for diagnosis, one should…

Posted in: constipation 5 diarrhea 10 irritable bowel syndrome 7

Expired CME Article

Clostridium difficile: An Update for the Primary Care Clinician

Clostridium difficile infection (CDI) is an important cause of intestinal disease, primarily affecting hospitalized patients exposed to antibiotics. Infection has been associated with prolonged hospital stays and excess healthcare expenditures. Recent changes in the epidemiology, pathogenesis, and treatment of CDI have occurred, leading to renewed scrutiny of this pathogen. Increases…

Posted in: Clostridium difficile 10 diarrhea 10

Case Report

Whipple Disease

Whipple disease (WD) is a rare disease caused by Tropheryma whipplei. The classic profile of the patient is that of a middle-aged man presenting with fever, chronic diarrhea, and arthralgias. Extragastrointestinal manifestations are not rare. A high degree of clinical suspicion for the disease is needed in atypical cases. Trimethoprim-sulfamethoxazole…

Posted in: diarrhea 10

Review Article

Nissen Fundoplication and Gastrointestinal-Related Complications: A Guide for the Primary Care Physician

Abstract:Gastroesophageal reflux disease is a common condition affecting many individuals in the Western world. Most patients are managed successfully with acid suppression, while others may require more invasive interventions. The majority of patients undergoing antireflux surgery will have favorable outcomes. A small percentage, however, will be considered surgical failures and…

Posted in: diarrhea 10 dysphagia 4 Nissen fundoplication 2

Original Article

Is It Clostridium difficile Infection or Something Else? A Case-control Study of 352 Hospitalized Patients With New-onset Diarrhea

Background: Clostridium difficile-associated diarrhea (CDAD) is a leading cause of nosocomial diarrhea in the United States, and may be associated with significant morbidity and occasional mortality. Diarrhea is also very common among hospitalized patients and is often related to a variety of factors not related to C difficile infection. Methods:…

Posted in: Clostridium difficile 10 diarrhea 10 hospital 3 Patients 3

Expired CME Article

Irritable Bowel Syndrome: A Practical Review

The epidemiology and current understanding of the pathophysiology of irritable bowel syndrome is reviewed, beginning with a historical perspective. The roles of genetics, environment, allergy, infection and inflammation, bacterial overgrowth, hormones and motility abnormalities are discussed. Using the current evidence-based literature, the practical approach of diagnosis and treatment is outlined,…

Posted in: constipation 5 diarrhea 10 irritable bowel syndrome 7

Original Article

Compassionate-use Oxaliplatin with Bolus 5-Fluorouracil/Leucovorin in Heavily Pretreated Patients with Advanced Colorectal Cancer

Objectives: The efficacy of a concomitant oxaliplatin/bolus 5-fluorouracil/leucovorin regimen in 123 heavily pretreated patients with advanced colorectal cancer was evaluated. Patients with an Eastern Cooperative Oncology Group performance status of 0 to 2 and radiographically progressive cancer which failed to respond to between two and five prior treatment modalities were…

Posted in: colorectal cancer 17 diarrhea 10

Case Report

Cytomegalovirus Enteritis in Common Variable Immunodeficiency

A woman with previously undiagnosed common variable immunodeficiency presented with diarrhea and volume depletion. Biopsies from upper and lower endoscopy revealed atrophic gastritis, villous atrophy, and an inflammatory bowel disease-like chronic colitis, with absence of plasma cells in all sites. Cytomegalovirus inclusions were demonstrated in the colon and small bowel…

Posted in: common variable immunodeficiency 2 cytomegalovirus 2 diarrhea 10
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