SMJ articles in the category "thrombotic thrombocytopenic purpura"

CME Topic

Thrombotic Thrombocytopenic Purpura: The Masquerader

Abstract:Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder with a mortality rate of up to 90% if left untreated, and is characterized by microvascular thrombi, mainly in small arteries and capillaries, thrombocytopenia, hemolysis, and neurological abnormalities. Malignant hypertension (HTN) is a clinical syndrome characterized by severe hypertension associated with end-organ…

Posted in: microangiopathic hemolytic anemia 2 thrombotic microangiopathy 3 thrombotic thrombocytopenic purpura 6

Case Report

Rituximab Therapy for Refractory Thrombotic Thrombocytopenic Purpura and Autoimmune-Mediated Thrombocytopenia in Systemic Lupus Erythematosus

Abstract:Thrombotic thrombocytopenic purpura (TTP) rarely occurs in the setting of systemic lupus erythematosus (SLE); when it does occur it has a high mortality rate and is refractory to conventional treatment. No clear treatment guidelines exist when refractory TTP occurs in the setting of SLE. A 24-year-old male patient presented with…

Posted in: plasmapheresis 2 rituximab 4 systemic lupus erythematosus 9 thrombotic thrombocytopenic purpura 6

Case Report

The Spectrum of Thrombotic Thrombocytopenic Purpura: A Clinicopathologic Demonstration of Tacrolimus-Induced Thrombotic Thrombocytopenic Purpura in a Lung Transplant Patient

Immunosuppressive drugs used post-transplantation are among the most common causes of thrombotic thrombocytopenic purpura (TTP). Diagnosis is often confounded not only by its myriad presentations, but also because these manifestations may be explained by the comorbidities or complications of transplantation. A 61-year-old female who had a single lung transplant for…

Posted in: lung transplant 2 thrombotic microangiopathy 3 thrombotic thrombocytopenic purpura 6

Original Article

Elevated Red Cell Distribution Width in the Diagnosis of Thrombotic Thrombocytopenic Purpura in Patients Presenting with Anemia and Thrombocytopenia

Objective: To determine if red cell distribution width (RDW) is elevated in thrombotic thrombocytopenic purpura (TTP) and to evaluate the sensitivity and specificity of such elevation in the diagnosis of TTP. Methods: We retrospectively studied red cell distribution width at presentation in 25 consecutive patients with newly diagnosed TTP who…

Posted in: thrombotic thrombocytopenic purpura 6

Case Report

Thrombotic Thrombocytopenic Purpura Without Schistocytes on the Peripheral Blood Smear

A hallmark of the clinical syndrome of thrombotic thrombocytopenic purpura (TTP) is evidence of microangiopathic hemolytic anemia. The presence of schistocytes on the peripheral blood smear, elevated plasma lactic dehydrogenase, and decreased haptoglobin concentration are used as evidence of microangiopathic hemolytic anemia to make a diagnosis of TTP. This report…

Posted in: plasma exchange 2 renal failure 10 thrombotic thrombocytopenic purpura 6

Case Report

Bee Envenomation: A Rare Cause of Thrombotic Thrombocytopenic Purpura

Thrombotic thrombocytopenic purpura (TTP) is characterized by the pentad of microangiopathic hemolytic anemia, thrombocytopenia, neurologic symptoms, renal insufficiency, and fever. Although many underlying diseases and conditions are associated with TTP, there has been only one previously documented case of bee-sting-associated TTP. In this article, we describe the case of a…

Posted in: microangiopathic hemolytic anemia 2 plasma exchange 2 thrombotic thrombocytopenic purpura 6 von Willebrand factor 2
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